QuickView for BCL2L11 (gene)

Gene Symbol:

BCL2L11 Homo sapiens

Full name:

BCL2 like 11

Synonyms:

BAM, BIM, BOD, bcl-2-like protein 11, BCL2-like 11 (apoptosis facilitator), bcl-2 interacting mediator of cell death, bcl-2 interacting protein Bim, bcl-2-related ovarian death agonist

Genomic Location:

Chr 2: 111594962-111642493

Description:

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of ...

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The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  SYATTGTG_UNKNOWN ,  YTATTTTNR_MEF2_02 ,  CATTGTYY_SOX9_B1 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GTACTGT_MIR101 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  SOX9_B1 ,  GTGACGY_E4F1_Q6 ,  CCTGTGA_MIR513 ,  EGR_Q6 ,  TGCCTTA_MIR124A ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  HIF1_Q5 ,  GTGCCTT_MIR506 ,  TCTATGA_MIR376A_MIR376B ,  TTGTTT_FOXO4_01 ,  AP2REP_01 ,  CHOP_01 ,  CTGAGCC_MIR24 ,  CTTTGT_LEF1_Q2 ,  CTGTTAC_MIR194 ,  HIF1_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-496

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Cytogenetic Map:

2q13

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