QuickView for BDKRB2 (gene)
- Gene Symbol:
- BDKRB2
Homo sapiens - Full name:
- bradykinin receptor B2
- Synonyms:
- B2R, BK-2, BK2, BKR2, BRB2, B2 bradykinin receptor, BK-2 receptor
- Genomic Location:
- Chr 14: 95740950-95780542
- Description:
-
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Canis lupus familiaris , Gallus gallus , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
14q32.2
GO Molecular Function
phospholipase activity | type 1 angiotensin receptor binding | transmembrane signaling receptor activity | enzyme binding | G-protein coupled receptor activity | signaling receptor binding | hydrolase activity | catalytic activity | signaling receptor activity | hydrolase activity, acting on ester bonds | protein heterodimerization activity | angiotensin receptor binding | lipase activity | protein binding | protein dimerization activity | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | G-protein coupled receptor binding | bradykinin receptor activity | phosphatidylinositol phospholipase C activity | peptide receptor activity | G-protein coupled peptide receptor activity | phospholipase C activity | protease binding
GO Biological Process
negative regulation of phosphorylation | long-chain fatty acid transport | regulation of blood vessel diameter | lipid transport | regulation of programmed cell death | establishment of localization | negative regulation of cellular process | defense response | negative regulation of protein phosphorylation | cellular chemical homeostasis | cellular process | secretion | monocarboxylic acid transport | localization | cellular homeostasis | negative regulation of signaling | negative regulation of peptidyl-serine phosphorylation | anion transport | macromolecule localization | regulation of response to osmotic stress | negative regulation of apoptotic process | negative regulation of cellular metabolic process | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | smooth muscle contraction | calcium ion homeostasis | G-protein coupled receptor activity | muscle contraction | response to stimulus | acid secretion | regulation of blood vessel size | response to salt stress | response to stress | regulation of blood circulation | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | metal ion homeostasis | negative regulation of blood vessel diameter | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress | regulation of cellular response to stress | regulation of signal transduction | negative regulation of phosphate metabolic process | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | arachidonic acid secretion | fatty acid transport | organic substance transport | regulation of signal transduction by p53 class mediator | cellular ion homeostasis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | negative regulation of signal transduction by p53 class mediator | regulation of vascular permeability | organic acid transport | response to osmotic stress | regulation of cellular protein metabolic process | vasoconstriction | organic anion transport | regulation of apoptotic signaling pathway | cation homeostasis | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | inflammatory response | regulation of protein metabolic process | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | regulation of tube size | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cell surface receptor signaling pathway | regulation of vasoconstriction | vasodilation | lipid localization | negative regulation of programmed cell death | regulation of tube diameter | chemical homeostasis | negative regulation of intrinsic apoptotic signaling pathway | negative regulation of cellular protein metabolic process | ion homeostasis | regulation of phosphate metabolic process | bradykinin receptor activity | regulation of peptidyl-serine phosphorylation | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of signal transduction | signaling | G-protein coupled peptide receptor activity | carboxylic acid transport | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | cellular metal ion homeostasis | transmembrane receptor protein tyrosine kinase signaling pathway | ion transport | regulation of cell death | negative regulation of cell death | positive regulation of blood vessel diameter | divalent inorganic cation homeostasis | muscle system process | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endomembrane system | plasma membrane | vesicle | integral component of plasma membrane | endosome | membrane-bounded organelle | organelle | cell periphery | intracellular vesicle | intracellular | membrane | intrinsic component of plasma membrane
