QuickView for BDNF (gene)

Gene Symbol:

BDNF Homo sapiens

Full name:

brain derived neurotrophic factor

Synonyms:

ANON2, BULN2, brain-derived neurotrophic factor, abrineurin, neurotrophin

Genomic Location:

Chr 11: 27633016-27699872

Description:

This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Express...

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This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  GATTGGY_NFY_Q6_01 ,  MYOD_Q6_01 ,  SP1_01 ,  ACAACTT_MIR382 ,  OCT1_07 ,  RTAAACA_FREAC2_01 ,  STAT4_01 ,  PR_02 ,  CTCTATG_MIR368 ,  TGANTCA_AP1_C ,  CEBPA_01 ,  OCT1_B ,  HNF1_01 ,  STAT1_02 ,  TCANNTGAY_SREBP1_01 ,  RYTTCCTG_ETS2_B ,  ARNT_01 ,  MAZ_Q6 ,  EFC_Q6 ,  MIF1_01 ,  HOXA4_Q2 ,  HEN1_01 ,  FOXO4_01 ,  PR_01 ,  OCT_Q6 ,  GATA_C ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  SRF_Q6 ,  STAT6_02 ,  ATTACAT_MIR3803P ,  TTCCGTT_MIR191 ,  GCANCTGNY_MYOD_Q6 ,  AAAYWAACM_HFH4_01 ,  NGFIC_01 ,  PEA3_Q6 ,  EVI1_04 ,  CEBP_Q2_01 ,  IPF1_Q4 ,  LYF1_01 ,  AREB6_04 ,  WGTTNNNNNAAA_UNKNOWN ,  NFKAPPAB_01 ,  AMEF2_Q6 ,  ARNT_02 ,  STAT1_03 ,  ATGGYGGA_UNKNOWN ,  PBX1_01 ,  MYB_Q5_01 ,  RFX1_01 ,  OCT1_Q5_01 ,  TGACCTY_ERR1_Q2 ,  WHN_B ,  NFKAPPAB65_01 ,  MYAATNNNNNNNGGC_UNKNOWN ,  NRSF_01 ,  GGGAGGRR_MAZ_Q6 ,  YAATNRNNNYNATT_UNKNOWN ,  TATAAA_TATA_01 ,  CEBP_Q2 ,  CEBPDELTA_Q6 ,  OCT1_Q6 ,  RGAANNTTC_HSF1_01 ,  SREBP1_01 ,  ACATTCC_MIR1_MIR206 ,  GGGYGTGNY_UNKNOWN ,  FOXO3_01 ,  CAGGTA_AREB6_01 ,  CATGTAA_MIR496 ,  TEF1_Q6 ,  RREB1_01 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  TNCATNTCCYR_UNKNOWN ,  PXR_Q2 ,  TATA_C ,  TGCGCANK_UNKNOWN ,  SP3_Q3 ,  RRAGTTGT_UNKNOWN ,  AR_03 ,  GTTTGTT_MIR495 ,  ATGCTGC_MIR103_MIR107 ,  CAGNWMCNNNGAC_UNKNOWN ,  NF1_Q6 ,  GGGCGGR_SP1_Q6 ,  CEBPB_02 ,  YKACATTT_UNKNOWN ,  OCT1_03 ,  AHR_Q5 ,  MGGAAGTG_GABP_B ,  FOXO1_01 ,  RAAGNYNNCTTY_UNKNOWN ,  CTTTAAR_UNKNOWN ,  GCM_Q2 ,  TGCCAAR_NF1_Q6 ,  SPZ1_01 ,  USF_01 ,  PAX8_B ,  OCT1_06 ,  AHRARNT_01 ,  STAT_01 ,  AR_Q2 ,  RNGTGGGC_UNKNOWN ,  GFI1_01 ,  MYB_Q6 ,  NCX_01 ,  EN1_01 ,  TTGCCAA_MIR182 ,  FREAC2_01 ,  CEBP_Q3 ,  USF_Q6_01 ,  TAATTA_CHX10_01 ,  AACATTC_MIR4093P ,  TTGTTT_FOXO4_01 ,  GR_01 ,  CEBP_C ,  PIT1_Q6 ,  AFP1_Q6 ,  IK2_01 ,  MSX1_01 ,  STAT5A_04 ,  GATA1_05 ,  CP2_02 ,  ZIC2_01 ,  CTGCAGY_UNKNOWN ,  PAX_Q6 ,  TTCYNRGAA_STAT5B_01 ,  TACAATC_MIR508 ,  TGATTTRY_GFI1_01 ,  GRE_C ,  CTTTGT_LEF1_Q2 ,  STAT5A_01 ,  ER_Q6_02 ,  NFKB_Q6_01 ,  ISRE_01 ,  USF2_Q6 ,  AACTTT_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  TGACATY_UNKNOWN ,  ACAGGGT_MIR10A_MIR10B ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  USF_02 ,  PAX2_02 ,  RYTAAWNNNTGAY_UNKNOWN ,  NFKB_Q6 ,  NFKB_C ,  FOXO4_02 ,  PAX4_01 ,  SP1_Q2_01 ,  STAT5A_02 ,  MYB_Q3 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-191 ,  Predicted Gene Targets for miR-210 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-382 ,  Predicted Gene Targets for miR-147 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496

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miRNA binding sites
(Source: miRecords):

hsa-miR-1 Targeted Genes

Cytogenetic Map:

11p14.1

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