QuickView for BHLHE41 (gene)
- Gene Symbol:
- BHLHE41
Homo sapiens - Full name:
- basic helix-loop-helix family member e41
- Synonyms:
- BHLHB3, DEC2, SHARP1, hDEC2, class E basic helix-loop-helix protein 41, basic helix-loop-helix domain containing, class B, 3, differentially expressed in chondrocytes protein 2, enhancer-of-split and hairy-related protein 1
- Genomic Location:
- Chr 12: 26164226-26169113
- Description:
-
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this g...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Pan troglodytes , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
SP1_01 , ARNT_01 , VDR_Q3 , MYC_Q2 , CACGTG_MYC_Q2 , SMAD3_Q6 , TTTGTAG_MIR520D , HP1SITEFACTOR_Q6 , CAGCACT_MIR5123P , ATGTACA_MIR493
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-122a , Predicted Gene Targets for miR-130 , Predicted Gene Targets for miR-142-5p , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-200b , Predicted Gene Targets for miR-208 , Predicted Gene Targets for miR-151 , Predicted Gene Targets for miR-182 , Predicted Gene Targets for miR-493-5p
- Cytogenetic Map:
-
12p12.1
GO Molecular Function
sequence-specific DNA binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II transcription factor binding | proximal promoter sequence-specific DNA binding | enzyme binding | MRF binding | RNA polymerase II activating transcription factor binding | nucleic acid binding | transcriptional repressor activity, RNA polymerase II transcription factor binding | RNA polymerase II regulatory region DNA binding | E-box binding | bHLH transcription factor binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | identical protein binding | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | histone deacetylase binding | transcription coregulator activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | Notch signaling pathway | transcription factor activity, transcription factor binding | regulation of neurogenesis | regulation of cell development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | nervous system development | neurogenesis | generation of neurons | pattern specification process | cellular process | circadian regulation of gene expression | negative regulation of nucleic acid-templated transcription | transcription factor activity, RNA polymerase II transcription factor binding | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | regulation of myotube differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | response to stimulus | negative regulation of striated muscle cell differentiation | transcriptional repressor activity, RNA polymerase II transcription factor binding | cellular nitrogen compound biosynthetic process | circadian rhythm | rhythmic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cellular biosynthetic process | embryo development | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | multicellular organism development | regulation of gene expression | animal organ morphogenesis | regulation of nitrogen compound metabolic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | cell proliferation | biosynthetic process | aromatic compound biosynthetic process | negative regulation of myotube differentiation | chordate embryonic development | cell communication | regulation of cellular metabolic process | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | DNA-binding transcription factor activity | regionalization | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | regulation of striated muscle cell differentiation | transcription, DNA-templated | anatomical structure formation involved in morphogenesis | signaling | somite development | regulation of transcription, DNA-templated | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | negative regulation of transcription by competitive promoter binding | regulation of nervous system development | regulation of developmental process | segmentation | developmental process | regulation of muscle cell differentiation | negative regulation of transcription by RNA polymerase II | transcription coregulator activity | heterocycle metabolic process | somitogenesis | negative regulation of muscle cell differentiation | cellular metabolic process | negative regulation of cell differentiation | signal transduction | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular
