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QuickView for BRCA2 (gene)


Gene Symbol:
BRCA2 Homo sapiens Homo sapiens
Full name:
BRCA2, DNA repair associated
Synonyms:
BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer type 2 susceptibility protein, BRCA1/BRCA2-containing complex, subunit 2, Fanconi anemia group D1 protein, breast and ovarian cancer susceptibility gene, early onset, breast and ovarian cancer susceptibility protein 2, breast cancer 2 tumor suppressor, breast cancer 2, early onset, mutant BRCA2, truncated breast cancer 2
Genomic Location:
Chr 13: 31787617-31871809
Description:
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC moti...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 13
13q13.1


Transcripts Names
NM_000059
Protein Names
Q13879
O00183
Q5TBJ7
P51587
O15008



GO Molecular Function

N-acetyltransferase activity | transferase activity, transferring acyl groups other than amino-acyl groups | N-acyltransferase activity | enzyme binding | nucleic acid binding | single-stranded DNA binding | catalytic activity | cytoskeletal protein binding | transferase activity, transferring acyl groups | histone acetyltransferase activity | DNA binding | identical protein binding | organic cyclic compound binding | peptide N-acetyltransferase activity | H4 histone acetyltransferase activity | protein binding | transferase activity | peptide-lysine-N-acetyltransferase activity | tubulin binding | H3 histone acetyltransferase activity | gamma-tubulin binding | protease binding | acetyltransferase activity | heterocyclic compound binding | protein C-terminus binding

GO Biological Process

mitotic cytokinesis | response to extracellular stimulus | brain development | double-strand break repair | meiotic metaphase plate congression | response to radiation | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | telomere maintenance | response to nutrient levels | developmental process involved in reproduction | intracellular signal transduction | gonad development | female gonad development | peptidyl-amino acid modification | response to X-ray | regulation of meiotic cell cycle | establishment of localization | response to hormone | mitotic recombination-dependent replication fork processing | negative regulation of cellular process | meiotic recombination checkpoint | histone modification | microtubule cytoskeleton organization | cell differentiation | male gamete generation | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | multicellular organism growth | male meiotic nuclear division | histone H3 acetylation | meiotic DNA repair synthesis | regulation of DNA replication | regulation of organelle organization | negative regulation of DNA metabolic process | negative regulation of meiotic cell cycle | microtubule-based process | positive regulation of cellular biosynthetic process | cellular process | DNA-dependent DNA replication maintenance of fidelity | establishment of organelle localization | localization | chromatin organization | cell maturation | mitotic DNA replication maintenance of fidelity | developmental growth | reproductive system development | response to estradiol | cell cycle DNA replication | cytoskeleton-dependent cytokinesis | immune system development | multicellular organismal reproductive process | macromolecule localization | microtubule organizing center organization | inner cell mass cell proliferation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | mitotic DNA replication | establishment of localization in cell | negative regulation of cellular metabolic process | gamete generation | anatomical structure homeostasis | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of metabolic process | organelle localization | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | DNA-dependent DNA replication | cellular component organization | meiotic DNA repair synthesis involved in reciprocal meiotic recombination | establishment of chromosome localization | regulation of cell division | development of primary sexual characteristics | response to UV | head development | negative regulation of DNA replication | histone H4 acetylation | male meiosis I | response to stimulus | female gamete generation | chromosome segregation | response to stress | germ cell development | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of mammary gland epithelial cell proliferation | programmed cell death | development of primary female sexual characteristics | reproduction | cellular localization | peptidyl-lysine acetylation | cellular nitrogen compound metabolic process | telomere organization | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | cellular biosynthetic process | embryo development | DNA recombination | macromolecule modification | meiotic chromosome segregation | DNA repair | regulation of nucleic acid-templated transcription | apoptotic process | response to light stimulus | system development | nitrogen compound metabolic process | reproductive process | DNA damage response, signal transduction by p53 class mediator | replication fork processing | double-strand break repair via homologous recombination | multicellular organism development | protein acetylation | mammary gland development | cellular response to DNA damage stimulus | negative regulation of meiotic nuclear division | oocyte differentiation | histone acetyltransferase activity | DNA damage response, signal transduction resulting in transcription | positive regulation of cell cycle | positive regulation of mitotic cell cycle | signal transduction in response to DNA damage | regulation of gene expression | DNA biosynthetic process | cellular response to stress | response to lipid | cell cycle | positive regulation of cellular metabolic process | establishment of protein localization to chromosome | regulation of nitrogen compound metabolic process | response to nutrient | oogenesis | protein localization to organelle | negative regulation of mammary gland epithelial cell proliferation | DNA synthesis involved in double-strand break repair via homologous recombination | cell proliferation | histone acetylation | internal peptidyl-lysine acetylation | biosynthetic process | cell division | metaphase plate congression | aromatic compound biosynthetic process | cytokinesis | meiotic cell cycle checkpoint | regulation of DNA-dependent DNA replication | response to gamma radiation | nuclear chromosome segregation | chordate embryonic development | cell communication | regulation of cellular metabolic process | regulation of cytokinesis | meiotic metaphase I plate congression | homeostatic process | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | H4 histone acetyltransferase activity | apoptotic signaling pathway | cell aging | regulation of mitotic cell cycle | multicellular organism reproduction | homologous chromosome segregation | negative regulation of epithelial cell proliferation | protein metabolic process | centrosome duplication | response to organic substance | gland development | regulation of meiotic nuclear division | negative regulation of DNA-dependent DNA replication | centrosome cycle | protein localization to chromosome, telomeric region | DNA metabolic process | reciprocal meiotic recombination | establishment of protein localization to organelle | anatomical structure development | mitotic cell cycle | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | nuclear division | metabolic process | nucleotide-excision repair | homologous chromosome orientation involved in meiotic metaphase I plate congression | regulation of RNA biosynthetic process | developmental maturation | cellular protein localization | peptidyl-lysine modification | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of biosynthetic process | animal organ development | mitotic recombination | cytoskeleton organization | replication fork protection | telomere maintenance via recombination | intrinsic apoptotic signaling pathway by p53 class mediator | establishment of protein localization | blastocyst development | meiosis I | oocyte development | attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation | attachment of spindle microtubules to kinetochore | negative regulation of cell cycle | meiotic cell cycle | establishment of protein localization to telomere | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | response to organic cyclic compound | response to UV-C | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | cell development | internal protein amino acid acetylation | protein localization | regulation of epithelial cell proliferation | H3 histone acetyltransferase activity | cellular protein metabolic process | cellular macromolecule localization | cellular macromolecule biosynthetic process | homologous recombination | reproductive structure development | nuclear DNA replication | regulation of developmental process | recombinational repair | developmental process | organelle organization | spermatogenesis | blastocyst growth | cellular protein modification process | positive regulation of transcription, DNA-templated | DNA synthesis involved in DNA repair | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | oocyte maturation | heterocycle metabolic process | central nervous system development | in utero embryonic development | positive regulation of metabolic process | chromosome organization | immune system process | cellular metabolic process | attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | female sex differentiation | sex differentiation | cell cycle checkpoint | signal transduction by p53 class mediator | DNA replication | aging | sexual reproduction | regulation of cellular component organization | response to ionizing radiation | protein localization to chromosome | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

condensed nuclear chromosome | secretory granule | lateral element | chromosome | intracellular membrane-bounded organelle | microtubule organizing center | cytoplasmic vesicle | cell | nuclear lumen | synaptonemal complex | cytoplasm | BRCA2-MAGE-D1 complex | intracellular organelle | centrosome | protein-containing complex | secretory vesicle | endomembrane system | nucleoplasm | nuclear chromosome | vesicle | microtubule cytoskeleton | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular vesicle | cytoskeleton | nuclear chromosome, telomeric region | intracellular | condensed chromosome