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QuickView for BTRC (gene)


Gene Symbol:
BTRC Homo sapiens Homo sapiens
Full name:
beta-transducin repeat containing E3 ubiquitin protein ligase
Synonyms:
BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP, F-box/WD repeat-containing protein 1A, E3RSIkappaB, F-box and WD repeats protein beta-TrCP, F-box and WD-repeat protein 1B, beta-TrCP1, epididymis tissue protein Li 2a, pIkappaBalpha-E3 receptor subunit
Genomic Location:
Chr 10: 103103815-103307060
Description:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into ...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 10
10q24.32





GO Molecular Function

beta-catenin binding | protein phosphorylated amino acid binding | snoRNA binding | nucleic acid binding | catalytic activity | ubiquitin-like protein transferase activity | ubiquitin protein ligase activity | organic cyclic compound binding | phosphoprotein binding | protein binding | protein dimerization activity | ligase activity | ubiquitin-protein transferase activity | transferase activity | ubiquitin-like protein ligase activity | heterocyclic compound binding | RNA binding

GO Biological Process

RNA metabolic process | positive regulation of circadian rhythm | positive regulation of macromolecule biosynthetic process | protein dephosphorylation | response to cytokine | response to interleukin-1 | RNA processing | intracellular signal transduction | proteolysis | mammary gland duct morphogenesis | morphogenesis of an epithelium | negative regulation of cellular process | negative regulation of RNA biosynthetic process | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | epithelial tube morphogenesis | proteolysis involved in cellular protein catabolic process | negative regulation of signaling | negative regulation of nucleic acid-templated transcription | regulation of proteolysis | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | ribosome biogenesis | regulation of canonical Wnt signaling pathway | regulation of smoothened signaling pathway | negative regulation of cellular metabolic process | tissue development | interspecies interaction between organisms | regulation of cellular process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | epithelium development | cellular aromatic compound metabolic process | MAPK cascade | mammary gland morphogenesis | response to stimulus | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | regulation of cellular protein catabolic process | gland morphogenesis | response to stress | tube morphogenesis | ncRNA processing | protein destabilization | cellular protein catabolic process | rhythmic process | positive regulation of proteolysis | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | macromolecule modification | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | regulation of signal transduction | Wnt signaling pathway | regulation of protein stability | multicellular organism development | phosphorus metabolic process | mammary gland development | regulation of gene expression | cellular response to stress | cell cycle | protein catabolic process | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | interleukin-1-mediated signaling pathway | cytokine-mediated signaling pathway | negative regulation of DNA-binding transcription factor activity | ubiquitin protein ligase activity | cellular response to cytokine stimulus | cell proliferation | stress-activated MAPK cascade | regulation of cellular protein metabolic process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | G2/M transition of mitotic cell cycle | phosphorylation | mammary gland epithelial cell proliferation | rRNA metabolic process | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | cell cycle G2/M phase transition | regulation of RNA metabolic process | viral process | rRNA processing | proteasome-mediated ubiquitin-dependent protein catabolic process | protein polyubiquitination | protein metabolic process | response to organic substance | gland development | protein ubiquitination | tissue morphogenesis | branching morphogenesis of an epithelial tube | epithelial cell proliferation | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cellular macromolecule catabolic process | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | ubiquitin-protein transferase activity | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of proteasomal protein catabolic process | maturation of SSU-rRNA | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | protein modification by small protein conjugation or removal | regulation of Wnt signaling pathway | mammary gland epithelium development | morphogenesis of a branching epithelium | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | regulation of cell communication | dephosphorylation | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular protein metabolic process | morphogenesis of a branching structure | anatomical structure morphogenesis | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | regulation of circadian rhythm | developmental process | negative regulation of smoothened signaling pathway | cellular response to interleukin-1 | cellular protein modification process | tube development | positive regulation of transcription, DNA-templated | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | cell cycle phase transition | NIK/NF-kappaB signaling | heterocycle metabolic process | ribosomal small subunit biogenesis | positive regulation of metabolic process | ribonucleoprotein complex biogenesis | cellular metabolic process | cellular response to organic substance | modification-dependent protein catabolic process | branching involved in mammary gland duct morphogenesis | regulation of I-kappaB kinase/NF-kappaB signaling | signal transduction | regulation of signaling | positive regulation of gene expression | post-translational protein modification | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | ubiquitin ligase complex | 90S preribosome | protein-containing complex | nucleoplasm | ribonucleoprotein complex | transferase complex | cullin-RING ubiquitin ligase complex | membrane-bounded organelle | preribosome | nucleus | organelle | membrane-enclosed lumen | SCF ubiquitin ligase complex | small-subunit processome | cytosol | intracellular | Pwp2p-containing subcomplex of 90S preribosome