QuickView for Bak (gene)

Gene Symbol:

BAK1 Homo sapiens

Full name:

BCL2 antagonist/killer 1

Synonyms:

BAK, BAK-LIKE, BCL2L7, CDN1, bcl-2 homologous antagonist/killer, BCL2-like 7 protein, apoptosis regulator BAK, bcl-2-like protein 7, bcl2-L-7, pro-apoptotic protein BAK

Genomic Location:

Chr 6: 33648301-33656048

Description:

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of t...

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The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TACTTGA_MIR26A_MIR26B ,  CTCAGGG_MIR125B_MIR125A ,  TGGTGCT_MIR29A_MIR29B_MIR29C

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-29

miRNA binding sites
(Source: miRecords):

hsa-miR-125b Targeted Genes

Cytogenetic Map:

6p21.31

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