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QuickView for Bambuterol (compound)
PubChem
| Name: | bambuterol |
|---|---|
| PubChem Compound ID: | 11726467 |
| Molecular formula: | C18H29N3O5 |
| Molecular weight: | 367.44 g/mol |
DrugBank
Identification
| Name: | bambuterol |
|---|---|
| Name (isomeric): | DB01408 |
| Drug Type: | small molecule |
| Synonyms: |
Bambuterol hydrochloride
|
| Brand: | Bambec, Oxeol |
| Category: | Tocolytic Agents, Adrenergic beta-Agonists, Sympathomimetics, Bronchodilator Agents |
| CAS number: | 81732-46-9 |
Pharmacology
| Indication: | For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema. |
|---|---|
| Pharmacology: | Bambuterol is a long acting beta2-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline. Bambuterol causes smooth muscle relaxation, resulting in dilation of bronchial passages. |
| Mechanism of Action: |
The pharmacologic effects of bambuterol are at least in part attributable to stimulation through beta-adrenergic receptors (beta 2 receptors) of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle a...
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| Absorption: | Bioavailability is 20% following oral administration. |
| Biotransformation: | Hepatic, extensive. Further metabolized to terbutaline by plasma cholinesterase. |
| Half Life: | 13 hours for bambuterol and 21 hours for the primary active metabolite terbutaline. |
| Affected organisms: | Humans and other mammals |
Targets
Enzymes
