QuickView for Bcl11b (gene)

Gene Symbol:

BCL11B Homo sapiens

Full name:

B cell CLL/lymphoma 11B

Synonyms:

ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, CTIP-2, CTIP2, IMD49, RIT1, ZNF856B, hRIT1-alpha, B-cell lymphoma/leukemia 11B, B-cell CLL/lymphoma 11B (zinc finger protein), B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion protein, B-cell lymphoma/leukaemia 11B, BCL-11B, BCL11B/TRDC fusion, COUP-TF-interacting protein 2, hRit1, radiation-induced tumor suppressor gene 1 protein, zinc finger protein hRit1 alpha

Genomic Location:

Chr 14: 98705377-98807575

Description:

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone...

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This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  NKX25_01 ,  CRGAARNNNNCGA_UNKNOWN ,  ACAACCT_MIR453 ,  CTTGTAT_MIR381 ,  SP1_01 ,  ACAACTT_MIR382 ,  OCT1_07 ,  NFMUE1_Q6 ,  RTAAACA_FREAC2_01 ,  FREAC7_01 ,  HNF3ALPHA_Q6 ,  GTGTTGA_MIR505 ,  TAL1ALPHAE47_01 ,  AAGCCAT_MIR135A_MIR135B ,  CCCAGAG_MIR326 ,  GNCF_01 ,  MZF1_01 ,  ARNT_01 ,  OCT1_04 ,  FOX_Q2 ,  P53_DECAMER_Q2 ,  AAAGGGA_MIR204_MIR211 ,  HFH3_01 ,  VDR_Q3 ,  ATGTCAC_MIR489 ,  FOXO4_01 ,  POU3F2_01 ,  CACGTG_MYC_Q2 ,  AAAYWAACM_HFH4_01 ,  NGFIC_01 ,  FOXD3_01 ,  CTTTGCA_MIR527 ,  HFH1_01 ,  CIZ_01 ,  EVI1_04 ,  XBP1_01 ,  TGAGATT_MIR216 ,  RNCTGNYNRNCTGNY_UNKNOWN ,  TAGCTTT_MIR9 ,  ATGGYGGA_UNKNOWN ,  GGGCATT_MIR365 ,  MYCMAX_B ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  HNF4_01 ,  SOX9_B1 ,  CATTTCA_MIR203 ,  FOXO3_01 ,  CAGGTA_AREB6_01 ,  GTGACGY_E4F1_Q6 ,  LFA1_Q6 ,  CEBP_01 ,  FREAC3_01 ,  P53_02 ,  CAGGTG_E12_Q6 ,  AP4_Q6 ,  SP1_Q4_01 ,  EVI1_02 ,  TATA_C ,  HNF3_Q6 ,  RRAGTTGT_UNKNOWN ,  ATTCTTT_MIR186 ,  GTTTGTT_MIR495 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  HNF3B_01 ,  FOXJ2_01 ,  GGGCGGR_SP1_Q6 ,  AAGGGAT_MIR188 ,  HIF1_Q5 ,  AHR_Q5 ,  CTCTGGA_MIR520A_MIR525 ,  FOXO1_01 ,  TAATAAT_MIR126 ,  CTTTAAR_UNKNOWN ,  E47_01 ,  AP2_Q3 ,  HFH4_01 ,  SP1_Q6 ,  TGTTTGY_HNF3_Q6 ,  HFH8_01 ,  WCTCNATGGY_UNKNOWN ,  GTGCCTT_MIR506 ,  AATGTGA_MIR23A_MIR23B ,  GGCACTT_MIR519E ,  FREAC2_01 ,  CEBP_Q3 ,  TTGTTT_FOXO4_01 ,  CEBP_C ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  YY1_02 ,  CP2_02 ,  TGCTTTG_MIR330 ,  TAL1BETAITF2_01 ,  CTTTGT_LEF1_Q2 ,  PAX3_B ,  CAGCTG_AP4_Q5 ,  CDC5_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  MZF1_02 ,  TCF1P_Q6 ,  HIF1_Q3 ,  AGGAAGC_MIR5163P ,  HNF6_Q6 ,  HTF_01 ,  SP1_Q2_01 ,  CCTNTMAGA_UNKNOWN ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-382 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-499 ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-544 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

14q32.2

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