QuickView for Bcl1 (gene)

Gene Symbol:

CCND1 Homo sapiens

Full name:

cyclin D1

Synonyms:

BCL1, D11S287E, PRAD1, U21B31, G1/S-specific cyclin-D1, B-cell CLL/lymphoma 1, B-cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene

Genomic Location:

Chr 11: 69165054-69178423

Description:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination ...

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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

OCT1_07 ,  NFMUE1_Q6 ,  RTAAACA_FREAC2_01 ,  TFIIA_Q6 ,  STAT1_02 ,  OCT1_04 ,  OCT1_01 ,  HOXA4_Q2 ,  YATGNWAAT_OCT_C ,  YTATTTTNR_MEF2_02 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  CIZ_01 ,  TTTGTAG_MIR520D ,  IPF1_Q4 ,  XBP1_01 ,  CGCTGCT_MIR503 ,  STAT1_03 ,  PBX1_01 ,  MYCMAX_B ,  CREB_Q3 ,  GGGAGGRR_MAZ_Q6 ,  CDP_01 ,  TAATGTG_MIR323 ,  ATGCTGG_MIR338 ,  YY1_Q6 ,  CCTGTGA_MIR513 ,  YYCATTCAWW_UNKNOWN ,  ATACCTC_MIR202 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  ATF3_Q6 ,  FOXO1_01 ,  IRF_Q6 ,  AAAGACA_MIR511 ,  HFH4_01 ,  HFH8_01 ,  AHR_01 ,  RNGTGGGC_UNKNOWN ,  AATGTGA_MIR23A_MIR23B ,  ATF1_Q6 ,  PIT1_Q6 ,  YY1_02 ,  TEF_Q6 ,  TGATTTRY_GFI1_01 ,  AAGCACT_MIR520F ,  CTTTGT_LEF1_Q2 ,  BRN2_01 ,  GGCKCATGS_UNKNOWN ,  PAX2_02 ,  STTTCRNTTT_IRF_Q6 ,  HTF_01 ,  HOX13_01 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-93

miRNA binding sites
(Source: miRecords):

[miR-16-1] Targeted Genes ,  hsa-let-7b Targeted Genes

Cytogenetic Map:

11q13.3

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