QuickView for Bcl2 (gene)
- Gene Symbol:
- BCL2
Homo sapiens - Full name:
- BCL2, apoptosis regulator
- Synonyms:
- Bcl-2, PPP1R50, apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, protein phosphatase 1, regulatory subunit 50
- Genomic Location:
- Chr 18: 58941559-59137593
- Description:
-
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Danio rerio , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
NKX25_01 , SP1_01 , OCT1_05 , TTTGCAG_MIR518A2 , OCT1_B , AAAGGGA_MIR204_MIR211 , ATGTACA_MIR493 , OCT1_Q5_01 , OCT_C , ATAGGAA_MIR202
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-143 , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-153 , Predicted Gene Targets for miR-181 , Predicted Gene Targets for miR-204 , Predicted Gene Targets for miR-205 , Predicted Gene Targets for miR-21 , Predicted Gene Targets for miR-217 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-34
- miRNA binding sites
(Source: miRecords):
- Cytogenetic Map:
-
18q21.33
GO Molecular Function
sequence-specific DNA binding | protein phosphatase 2A binding | channel regulator activity | passive transmembrane transporter activity | enzyme binding | nucleic acid binding | transmembrane transporter activity | molecular function regulator | protein domain specific binding | ubiquitin-like protein ligase binding | channel inhibitor activity | DNA binding | transporter activity | identical protein binding | protein heterodimerization activity | organic cyclic compound binding | protein binding | protein homodimerization activity | death domain binding | protein phosphatase binding | transcription factor binding | ubiquitin protein ligase binding | BH3 domain binding | protein dimerization activity | channel activity | protease binding | phosphatase binding | BH domain binding | heterocyclic compound binding
GO Biological Process
positive regulation of immune response | leukocyte homeostasis | response to extracellular stimulus | brain development | positive regulation of striated muscle cell differentiation | molting cycle | response to radiation | cell morphogenesis | regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell cycle process | cellular response to glucose starvation | cellular response to decreased oxygen levels | positive regulation of locomotion | response to virus | response to nutrient levels | actin filament-based process | response to endoplasmic reticulum stress | protein dephosphorylation | epidermis morphogenesis | release of cytochrome c from mitochondria | response to cytokine | positive regulation of cellular component organization | regulation of B cell activation | regulation of neurogenesis | neuron projection morphogenesis | behavioral fear response | immune response-regulating signaling pathway | developmental process involved in reproduction | regulation of cellular localization | intracellular signal transduction | ovarian follicle development | positive regulation of skeletal muscle tissue development | positive regulation of apoptotic process | regulation of cell development | homeostasis of number of cells within a tissue | regulation of localization | regulation of cell cycle G1/S phase transition | cell-substrate adhesion | morphogenesis of an epithelium | positive regulation of striated muscle tissue development | gonad development | regulation of programmed cell death | female gonad development | T cell lineage commitment | peptidyl-amino acid modification | defense response to other organism | actin cytoskeleton organization | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of autophagy | regulation of osteoblast proliferation | regulation of immune system process | response to hormone | neuron death | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | CD8-positive, alpha-beta T cell differentiation | response to metal ion | positive regulation of lymphocyte activation | regulation of protein localization to membrane | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of melanocyte differentiation | adherens junction assembly | positive regulation of intrinsic apoptotic signaling pathway | defense response | glomerulus development | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | cellular response to extracellular stimulus | response to drug | reactive oxygen species metabolic process | organ growth | cellular chemical homeostasis | cell part morphogenesis | regulation of G1/S transition of mitotic cell cycle | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | membrane organization | B cell differentiation | response to antibiotic | mesenchyme development | tissue homeostasis | phenol-containing compound metabolic process | regulation of neuron death | melanin metabolic process | focal adhesion assembly | cellular process | channel regulator activity | lymphocyte differentiation | regulation of cell motility | localization | cellular homeostasis | cell projection morphogenesis | epithelial tube morphogenesis | extrinsic apoptotic signaling pathway | positive regulation of neuron maturation | lymphoid progenitor cell differentiation | passive transmembrane transporter activity | regulation of mitochondrial membrane potential | negative regulation of signaling | developmental growth | positive regulation of peptidyl-serine phosphorylation | neuron development | negative regulation of G1/S transition of mitotic cell cycle | cell-substrate adherens junction assembly | reproductive system development | negative regulation of anoikis | negative regulation of retinal cell programmed cell death | female pregnancy | immune system development | multicellular organismal reproductive process | renal tubule morphogenesis | regulation of striated muscle tissue development | negative regulation of apoptotic process | branching involved in ureteric bud morphogenesis | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | digestive tract morphogenesis | response to hypoxia | cellular response to starvation | regulation of cell cycle | positive regulation of catalytic activity | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | gamete generation | positive regulation of muscle cell differentiation | anatomical structure homeostasis | cell junction assembly | intrinsic apoptotic signaling pathway | regulation of myotube differentiation | negative regulation of apoptotic signaling pathway | regeneration | response to hydrogen peroxide | negative regulation of cell motility | regulation of immune response | regulation of cellular process | leukocyte activation | positive regulation of cell growth | regulation of apoptotic process | regulation of skeletal muscle fiber development | regulation of metabolic process | transmembrane transporter activity | organic cyclic compound metabolic process | regulation of cell maturation | positive regulation of cellular protein metabolic process | epithelium development | cellular aromatic compound metabolic process | regulation of mitochondrial depolarization | pons development | cellular component organization | calcium ion homeostasis | urogenital system development | T cell activation | nephron tubule morphogenesis | development of primary sexual characteristics | response to UV | head development | response to stimulus | peptidyl-threonine phosphorylation | thymus development | female gamete generation | cell morphogenesis involved in neuron differentiation | regulation of glycoprotein biosynthetic process | regulation of cellular protein localization | mesenchymal cell development | regulation of mitotic cell cycle phase transition | metencephalon development | positive regulation of immune system process | CD8-positive, alpha-beta T cell lineage commitment | positive regulation of protein metabolic process | negative regulation of myeloid cell apoptotic process | mononuclear cell proliferation | cellular response to hypoxia | gland morphogenesis | response to stress | germ cell development | positive regulation of cellular protein localization | positive regulation of lymphocyte proliferation | regulation of cell proliferation | multicellular organismal homeostasis | tube morphogenesis | regulation of cell cycle phase transition | positive regulation of B cell proliferation | response to starvation | hematopoietic progenitor cell differentiation | regulation of smooth muscle cell migration | regulation of protein homodimerization activity | pigment cell differentiation | programmed cell death | development of primary female sexual characteristics | supramolecular fiber organization | positive regulation of cell activation | regulation of developmental pigmentation | reproduction | response to ischemia | negative regulation of cellular pH reduction | immune response-activating signal transduction | negative regulation of transport | extrinsic apoptotic signaling pathway via death domain receptors | apoptotic mitochondrial changes | negative regulation of metabolic process | hemopoiesis | cellular component assembly | regulation of anoikis | protein modification process | regulation of cell adhesion | kidney development | positive regulation of multicellular organism growth | mitochondrion organization | response to iron ion | macromolecule modification | B cell receptor signaling pathway | molecular function regulator | metal ion homeostasis | positive regulation of mitochondrion organization | regulation of membrane potential | leukocyte differentiation | organic hydroxy compound metabolic process | negative regulation of neuron apoptotic process | apoptotic process | regulation of calcium ion transport into cytosol | response to light stimulus | positive regulation of mononuclear cell proliferation | regulation of skeletal muscle tissue development | response to nicotine | response to external biotic stimulus | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | ureteric bud development | negative regulation of growth | regulation of protein stability | channel inhibitor activity | adherens junction organization | multicellular organism development | pigment granule organization | phosphorus metabolic process | regulation of neuron maturation | actin filament organization | positive regulation of smooth muscle cell migration | positive regulation of skeletal muscle fiber development | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | cellular response to DNA damage stimulus | positive regulation of muscle organ development | spleen development | regulation of catalytic activity | cellular response to oxidative stress | oocyte differentiation | regulation of phosphorylation | kidney morphogenesis | regulation of intrinsic apoptotic signaling pathway | regulation of ossification | hair follicle morphogenesis | regulation of neuron differentiation | regulation of gene expression | regulation of retinal cell programmed cell death | regulation of extrinsic apoptotic signaling pathway | kidney epithelium development | axon development | regulation of mitochondrial membrane permeability | cellular response to stress | response to lipid | alpha-beta T cell lineage commitment | positive regulation of pigment cell differentiation | regulation of membrane depolarization | response to UV-B | positive regulation of cellular metabolic process | defense response to virus | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular ion homeostasis | response to axon injury | animal organ morphogenesis | developmental pigmentation | mitochondrial transport | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of cell migration | regulation of cell-substrate adhesion | neuron apoptotic process | cytokine-mediated signaling pathway | cell-substrate junction assembly | positive regulation of intracellular signal transduction | response to corticosteroid | regulation of cellular component movement | alpha-beta T cell differentiation | oogenesis | response to oxidative stress | pigmentation | axonogenesis | B cell homeostasis | positive regulation of cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | homeostasis of number of cells | positive regulation of cell migration | cellular response to cytokine stimulus | B cell activation | cell proliferation | leukocyte proliferation | neuron projection regeneration | regulation of cellular protein metabolic process | positive regulation of cell maturation | hindbrain development | phosphorylation | mesonephric epithelium development | negative regulation of ion transport | digestive tract development | epidermis development | response to toxic substance | regulation of apoptotic signaling pathway | skin development | protein phosphorylation | cell morphogenesis involved in differentiation | response to gamma radiation | mesonephros development | post-embryonic development | cation homeostasis | phosphate-containing compound metabolic process | sensory organ development | negative regulation of autophagy | regulation of mitochondrion organization | mitochondrial membrane organization | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | positive regulation of protein localization to membrane | regulation of neuron apoptotic process | regulation of intracellular pH | metanephros development | renal tubule development | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | lymphocyte homeostasis | humoral immune response | negative regulation of calcium ion transport | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | renal system development | positive regulation of B cell activation | positive regulation of transport | negative regulation of cell growth | regulation of viral process | apoptotic signaling pathway | negative regulation of calcium ion transport into cytosol | cell aging | intrinsic apoptotic signaling pathway in response to oxidative stress | regulation of mitotic cell cycle | nephron development | lymphocyte activation | positive regulation of molecular function | protein polyubiquitination | neuron differentiation | regulation of nitrogen utilization | multicellular organism reproduction | T cell differentiation | negative regulation of mitochondrial depolarization | development of primary male sexual characteristics | ureteric bud morphogenesis | activation of immune response | multicellular organismal response to stress | fear response | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | hair cycle | T cell selection | response to organic substance | gland development | T cell differentiation in thymus | protein ubiquitination | tissue morphogenesis | digestive system development | branching morphogenesis of an epithelial tube | regulation of pH | male sex differentiation | response to wounding | regulation of animal organ morphogenesis | negative regulation of ossification | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | regulation of protein heterodimerization activity | cochlear nucleus development | cell surface receptor signaling pathway | positive regulation of neurogenesis | cell projection organization | metabolic process | positive regulation of cell development | cell fate commitment | mesenchymal cell differentiation | positive regulation of leukocyte activation | negative regulation of programmed cell death | male gonad development | negative regulation of mitotic cell cycle | positive T cell selection | ear development | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | hair cycle process | chemical homeostasis | behavior | positive regulation of cell death | cell adhesion | regulation of myeloid cell apoptotic process | immune response | neuron projection development | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | cell death | nephron morphogenesis | pigment metabolic process | animal organ development | response to reactive oxygen species | regulation of cell activation | negative regulation of cellular component movement | positive regulation of programmed cell death | alpha-beta T cell activation | ion homeostasis | protein modification by small protein conjugation or removal | skin epidermis development | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | cytoskeleton organization | antigen receptor-mediated signaling pathway | renal system process | T cell homeostasis | CD8-positive, alpha-beta T cell activation | positive regulation of muscle tissue development | vesicle organization | cell-cell adhesion | regulation of cellular pH | cell activation | oocyte development | morphogenesis of a branching epithelium | regulation of peptidyl-serine phosphorylation | negative regulation of cell cycle | positive regulation of developmental pigmentation | B cell lineage commitment | intracellular pH elevation | lymphocyte proliferation | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | regulation of membrane permeability | dephosphorylation | negative regulation of signal transduction | transmembrane transport | positive regulation of developmental growth | signaling | positive regulation of growth | cell-matrix adhesion | regulation of protein binding | response to organic cyclic compound | cellular monovalent inorganic cation homeostasis | cell development | regulation of developmental growth | negative regulation of osteoblast proliferation | regulation of transmembrane transporter activity | extrinsic apoptotic signaling pathway in absence of ligand | positive regulation of phosphorylation | cellular protein metabolic process | morphogenesis of a branching structure | anatomical structure morphogenesis | channel activity | response to biotic stimulus | reproductive structure development | axon regeneration | regulation of nervous system development | regulation of developmental process | regulation of ion transport | cell death in response to oxidative stress | melanocyte differentiation | endoplasmic reticulum calcium ion homeostasis | developmental process | organelle organization | regulation of muscle cell differentiation | behavioral defense response | cellular pigmentation | regulation of cell growth | peptidyl-serine phosphorylation | regulation of calcium ion transport | cellular protein modification process | B cell proliferation | tube development | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of B cell proliferation | negative regulation of cell proliferation | positive regulation of melanocyte differentiation | cellular metal ion homeostasis | central nervous system development | positive regulation of metabolic process | ossification | positive regulation of neuron differentiation | immune system process | cellular metabolic process | regulation of viral genome replication | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | female sex differentiation | cellular response to organic substance | regulation of protein localization | regulation of cell death | sex differentiation | positive regulation of cell motility | response to steroid hormone | regulation of viral life cycle | negative regulation of cell death | negative regulation of cell development | aging | divalent inorganic cation homeostasis | negative regulation of locomotion | sexual reproduction | nephron tubule development | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | positive regulation of apoptotic signaling pathway | response to other organism | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | positive regulation of myotube differentiation | neural nucleus development | hair follicle development | signal transduction | regulation of signaling | mesonephric tubule development | response to glucocorticoid | regulation of cell-matrix adhesion | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | organelle outer membrane | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | nuclear envelope | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial outer membrane | mitochondrial envelope | pore complex | membrane-enclosed lumen | outer membrane | mitochondrial membrane | cytosol | intracellular | myelin sheath | membrane
