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QuickView for Beclin1 (gene)


Gene Symbol:
BECN1 Homo sapiens Homo sapiens
Full name:
beclin 1
Synonyms:
ATG6, VPS30, beclin1, beclin-1, ATG6 autophagy related 6 homolog, beclin 1 (coiled-coil, moesin-like BCL2-interacting protein), beclin 1, autophagy related, coiled-coil myosin-like BCL2-interacting protein, testis secretory sperm-binding protein Li 215e
Genomic Location:
Chr 17: 38215678-38229807
Description:
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodege...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q21.31





GO Molecular Function

phosphatidylinositol 3-kinase binding | kinase binding | GTPase binding | protein kinase binding | enzyme binding | ubiquitin-like protein ligase binding | identical protein binding | protein binding | protein homodimerization activity | ubiquitin protein ligase binding | protein dimerization activity

GO Biological Process

protein modification by small protein removal | engulfment of apoptotic cell | response to extracellular stimulus | regulation of muscle system process | regulation of cell cycle process | cellular response to glucose starvation | response to virus | response to nutrient levels | positive regulation of cellular component organization | regulation of cellular localization | proteolysis | regulation of vacuole organization | phagocytosis, engulfment | protein localization to vacuole | regulation of localization | macroautophagy | regulation of programmed cell death | defense response to other organism | establishment of localization | regulation of autophagy | selective autophagy | negative regulation of cellular process | response to metal ion | cell differentiation | defense response | nervous system development | cellular response to extracellular stimulus | response to drug | neurogenesis | regulation of organelle organization | generation of neurons | membrane organization | response to antibiotic | intracellular transport | autophagy of mitochondrion | regulation of attachment of spindle microtubules to kinetochore | regulation of chromosome segregation | cellular process | organic substance catabolic process | establishment of organelle localization | localization | negative regulation of macroautophagy | neuron development | regulation of mitotic nuclear division | macromolecule localization | negative regulation of apoptotic process | response to hypoxia | cellular response to starvation | regulation of cell cycle | response to growth factor | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | positive regulation of autophagosome assembly | regulation of autophagosome assembly | cytosolic transport | positive regulation of cardiac muscle hypertrophy | interspecies interaction between organisms | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | organelle localization | regulation of attachment of mitotic spindle microtubules to kinetochore | protein localization by the Cvt pathway | cellular component organization | protein deubiquitination | establishment of chromosome localization | cellular response to metal ion | regulation of cell division | response to stimulus | chromosome segregation | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | vacuolar transport | regulation of cell proliferation | response to starvation | regulation of metaphase plate congression | programmed cell death | cellular response to inorganic substance | cellular localization | cellular nitrogen compound metabolic process | cellular response to toxic substance | positive regulation of attachment of mitotic spindle microtubules to kinetochore | regulation of macroautophagy | apoptotic cell clearance | negative regulation of metabolic process | cellular component assembly | protein modification process | negative regulation of autophagosome assembly | mitochondrion organization | response to iron ion | macromolecule modification | apoptotic process | organelle assembly | response to external biotic stimulus | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | autophagosome organization | cellular response to antibiotic | multicellular organism development | sister chromatid segregation | positive regulation of organelle assembly | response to vitamin E | regulation of catalytic activity | cellular response to oxidative stress | early endosome to late endosome transport | positive regulation of chromosome organization | cellular response to amino acid starvation | positive regulation of cell cycle | positive regulation of mitotic cell cycle | cellular response to stress | cell cycle | positive regulation of cellular metabolic process | defense response to virus | mitotic metaphase plate congression | positive regulation of attachment of spindle microtubules to kinetochore | positive regulation of intracellular signal transduction | cellular amide metabolic process | vesicle-mediated transport | response to nutrient | response to oxidative stress | positive regulation of vacuole organization | protein localization to organelle | response to iron(II) ion | cell division | metaphase plate congression | response to toxic substance | regulation of lysosome organization | vacuole organization | autophagy | negative regulation of autophagy | cellular response to drug | nuclear chromosome segregation | cellular response to aluminum ion | cell communication | regulation of cellular metabolic process | lysosome organization | regulation of cytokinesis | positive regulation of signal transduction | peptide metabolic process | viral process | regulation of mitotic cell cycle | organelle disassembly | cellular response to epidermal growth factor stimulus | neuron differentiation | negative regulation of lysosome organization | protein metabolic process | regulation of cardiac muscle hypertrophy | response to organic substance | receptor catabolic process | autophagosome assembly | import into cell | regulation of intracellular signal transduction | regulation of sister chromatid segregation | anatomical structure development | mitotic cell cycle | nuclear division | metabolic process | cellular response to nitrogen starvation | negative regulation of programmed cell death | cellular protein localization | membrane invagination | cellular response to hydrogen peroxide | endocytosis | cellular response to reactive oxygen species | positive regulation of cellular component biogenesis | organic substance metabolic process | response to copper ion | cell death | response to vitamin | response to reactive oxygen species | positive regulation of chromosome segregation | protein modification by small protein conjugation or removal | regulation of chromosome organization | late endosome to vacuole transport | mitotic nuclear division | positive regulation of autophagy | positive regulation of macroautophagy | response to epidermal growth factor | regulation of mitotic sister chromatid segregation | regulation of cell communication | mitophagy | response to mitochondrial depolarisation | response to organic cyclic compound | cell development | protein localization | cellular protein metabolic process | cellular macromolecule localization | response to biotic stimulus | developmental process | organelle organization | positive regulation of cell cycle process | cellular protein modification process | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | receptor metabolic process | cellular defense response | amyloid-beta metabolic process | response to aluminum ion | response to lead ion | response to amino acid starvation | positive regulation of metabolic process | chromosome organization | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | cellular response to copper ion | regulation of organelle assembly | negative regulation of cell death | aging | mitotic sister chromatid segregation | phagocytosis | regulation of cellular component organization | response to other organism | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | positive regulation of mitotic nuclear division | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

dendrite | intracellular membrane-bounded organelle | catalytic complex | phosphatidylinositol 3-kinase complex | neuron projection | extrinsic component of membrane | somatodendritic compartment | organelle membrane | cytoplasmic vesicle | cell | phosphatidylinositol 3-kinase complex, class III, type II | cytoplasm | intracellular organelle | endoplasmic reticulum | dendritic tree | endosome membrane | Golgi apparatus | phagophore assembly site | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | endomembrane system | endoplasmic reticulum membrane | vacuole | vesicle | transferase complex | mitochondrion | endosome | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | trans-Golgi network | phosphatidylinositol 3-kinase complex, class III | mitochondrial membrane | cytosol | intracellular vesicle | endocytic vesicle | intracellular | autophagosome | membrane | phosphatidylinositol 3-kinase complex, class III, type I | phagocytic vesicle