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QuickView for Bismuth Subsalicylate (compound)
PubChem
| Name: | bismuth subsalicylate |
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| PubChem Compound ID: | 11979775 |
| Molecular formula: | C71H58BiO24S2Zn |
| Molecular weight: | 1633.71 g/mol |
| Synonyms: |
Pepto-bismol; Bismuth, (2-hydroxybenzoato-O1,O2)oxo-, mixt. with 4-hydroxybenzenesulfonic acid zinc salt (2:1) and phenyl 2-hydroxybenzoate; 71156-53-1
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DrugBank
Identification
| Name: | bismuth subsalicylate |
|---|---|
| Name (isomeric): | DB01294 |
| Drug Type: | small molecule |
| Synonyms: |
Bismuth oxide salicylate; Bismuth(III) subsalicylate; Bismuth; Bismuthi subsalicylas; Bismutum subsalicylicum; Bismuth oxysalicylate
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| Brand: | Bismatrol, Bismuth chewables, Spiromak forte, Stabisol, Bismed, Wismutsubsalicylat, Maalox multi action, PMS-bismuth subsalicylate, Vismut, Bismuth caplets, Extra strength bismuth, Extra-strength bismuth, Pepto-bismol |
| Brand name mixture: | Watkins Settelz(Bismuth Subsalicylate + Pectin + Phenyl Salicylate), Pepto-Bismol Chewables(Bismuth Subsalicylate + Calcium Carbonate), Bismuth + Antacid [Chewable Tablets](Bismuth Subsalicylate + Calcium Carbonate) |
| Category: | Antidiarrheals |
| CAS number: | 14882-18-9 |
Pharmacology
| Indication: | Used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. |
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| Pharmacology: | Bismuth subsalicylate displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic. It can also cause a black tongue and black stools in some users of the drug, when it combines with trace amounts of sulfur in their saliva and gastrointestinal tract. This discoloration is temporary and harmless. |
| Mechanism of Action: |
As an antidiarrheal, the exact mechanism has not been determined. Bismuth subsalicylate may exert its antidiarrheal action not only by stimulating absorption of fluid and electrolytes across the intestinal wall (antisecretory action) but also, when hydrolyzed to salicylic acid, by inhibiting synthesis of a prostaglandin responsible for intestinal i...
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| Absorption: | Following oral administration, absorption of the salicylate component from the small intestine is generally rapid and complete (>90%). |
| Biotransformation: | Based on in vitro dissociation data and in vivo animal data, bismuth subsalicylate is believed to be largely hydrolyzed in the stomach to bismuth oxychloride and salicylic acid. In the small intestine, nondissociated bismuth subsalicylate reacts with other anions (bicarbonate and phosphate) to form insoluble bismuth salts. In the colon, nondissociated bismuth subsalicylate and other bismuth salts react with hydrogen sulfide to produce bismuth sulfide, a highly insoluble black salt responsible for the darkening of the stools. |
Interactions
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