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QuickView for Bismuth Subsalicylate (compound)

Name: bismuth subsalicylate
PubChem Compound ID: 11979775
Molecular formula: C71H58BiO24S2Zn
Molecular weight: 1633.71 g/mol
Pepto-bismol; Bismuth, (2-hydroxybenzoato-O1,O2)oxo-, mixt. with 4-hydroxybenzenesulfonic acid zinc salt (2:1) and phenyl 2-hydroxybenzoate; 71156-53-1
Name: bismuth subsalicylate
Name (isomeric): DB01294
Drug Type: small molecule
Bismuth oxide salicylate; Bismuth(III) subsalicylate; Bismuth; Bismuthi subsalicylas; Bismutum subsalicylicum; Bismuth oxysalicylate
Brand: Bismatrol, Bismuth chewables, Spiromak forte, Stabisol, Bismed, Wismutsubsalicylat, Maalox multi action, PMS-bismuth subsalicylate, Vismut, Bismuth caplets, Extra strength bismuth, Extra-strength bismuth, Pepto-bismol
Brand name mixture: Watkins Settelz(Bismuth Subsalicylate + Pectin + Phenyl Salicylate), Pepto-Bismol Chewables(Bismuth Subsalicylate + Calcium Carbonate), Bismuth + Antacid [Chewable Tablets](Bismuth Subsalicylate + Calcium Carbonate)
Category: Antidiarrheals
CAS number: 14882-18-9
Indication: Used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
Pharmacology: Bismuth subsalicylate displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic. It can also cause a black tongue and black stools in some users of the drug, when it combines with trace amounts of sulfur in their saliva and gastrointestinal tract. This discoloration is temporary and harmless.
Mechanism of Action:
As an antidiarrheal, the exact mechanism has not been determined. Bismuth subsalicylate may exert its antidiarrheal action not only by stimulating absorption of fluid and electrolytes across the intestinal wall (antisecretory action) but also, when hydrolyzed to salicylic acid, by inhibiting synthesis of a prostaglandin responsible for intestinal i...
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Absorption: Following oral administration, absorption of the salicylate component from the small intestine is generally rapid and complete (>90%).
Biotransformation: Based on in vitro dissociation data and in vivo animal data, bismuth subsalicylate is believed to be largely hydrolyzed in the stomach to bismuth oxychloride and salicylic acid. In the small intestine, nondissociated bismuth subsalicylate reacts with other anions (bicarbonate and phosphate) to form insoluble bismuth salts. In the colon, nondissociated bismuth subsalicylate and other bismuth salts react with hydrogen sulfide to produce bismuth sulfide, a highly insoluble black salt responsible for the darkening of the stools.
Drug interaction:
PrednisoneThe corticosteroid, prednisone, may decrease the effect of the salicylate, bismuth subsalicylate.
AtazanavirThis gastric pH modifier decreases the levels/effects of atazanavir
TetracyclineFormation of non-absorbable complexes
TriamcinoloneThe corticosteroid, triamcinolone, may decrease the effect of the salicylate, bismuth subsalicylate.
AcetazolamideThe salicylate, bismuth subsalicylate, at high dose increases the effect of the carbonic anhydrase inhibitor, acetazolamide.
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