QuickView for Bmi1 (gene)
- Gene Symbol:
- BMI1
Homo sapiens - Full name:
- BMI1 proto-oncogene, polycomb ring finger
- Synonyms:
- FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1, polycomb complex protein BMI-1, B lymphoma Mo-MLV insertion region 1 homolog, BMI1 polycomb ring finger oncogene, BMI1 polycomb ring finger proto-oncogene, murine leukemia viral (bmi-1) oncogene homolog, polycomb group RING finger protein 4, polycomb group protein Bmi1, ring finger protein 51
- Genomic Location:
- Chr 10: 22650146-22660194
- Description:
-
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage r...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Pan troglodytes , Canis lupus familiaris , Gallus gallus , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
10p12.2
GO Molecular Function
cation binding | chromatin binding | protein domain specific binding | promoter-specific chromatin binding | ion binding | protein binding | zinc ion binding | transition metal ion binding | metal ion binding | RING-like zinc finger domain binding
GO Biological Process
RNA metabolic process | regulation of cell cycle process | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | positive regulation of fibroblast proliferation | histone H2A ubiquitination | pattern specification process | cellular process | regulation of gene expression, epigenetic | chromatin organization | regulation of ubiquitin-protein transferase activity | immune system development | negative regulation of nucleic acid-templated transcription | histone H2A-K119 monoubiquitination | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | gene silencing | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | positive regulation of protein metabolic process | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of protein ubiquitination | cellular nitrogen compound metabolic process | negative regulation of metabolic process | hemopoiesis | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | protein monoubiquitination | histone H2A monoubiquitination | multicellular organism development | regulation of catalytic activity | regulation of gene expression | negative regulation of gene expression, epigenetic | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of transcription by RNA polymerase II | negative regulation of G0 to G1 transition | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of cell proliferation | regulation of RNA metabolic process | positive regulation of molecular function | protein metabolic process | regulation of fibroblast proliferation | regionalization | positive regulation of protein modification process | protein ubiquitination | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | protein modification by small protein conjugation or removal | regulation of G0 to G1 transition | transcription, DNA-templated | negative regulation of cell cycle | histone ubiquitination | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | segmentation | developmental process | organelle organization | cellular protein modification process | histone monoubiquitination | negative regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of ubiquitin-protein transferase activity | positive regulation of metabolic process | chromosome organization | chromatin silencing | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | positive regulation of protein ubiquitination | macromolecule metabolic process | multicellular organismal process | segment specification
GO Cellular Component
PRC1 complex | PcG protein complex | intracellular membrane-bounded organelle | catalytic complex | nuclear ubiquitin ligase complex | cell | nuclear lumen | cytoplasm | intracellular organelle | ubiquitin ligase complex | nuclear body | protein-containing complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
