QuickView for Boule (gene)

Gene Symbol:

BOLL Homo sapiens

Full name:

boule homolog, RNA binding protein

Synonyms:

BOULE, protein boule-like, bol, boule-like, boule-like RNA binding protein

Genomic Location:

Chr 2: 198299856-198359183

Description:

This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histol...

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This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTATTAT_MIR3693P ,  ATAAGCT_MIR21 ,  MZF1_01 ,  YTATTTTNR_MEF2_02 ,  GGGAGGRR_MAZ_Q6 ,  ATACCTC_MIR202 ,  GACTGTT_MIR212_MIR132 ,  GGCAGCT_MIR22 ,  KTGGYRSGAA_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-369-3p

Cytogenetic Map:

2q33.1

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