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QuickView for Breast cancer type 1 susceptibility protein (BRCA1) (biogroup)
- Description:
- Breast cancer is a common malignancy, affecting 1 in 8 women. A major contributary factor in disease development lies in a positive family history, a correlation that is striking for early-onset breast cancer. Mutations in the DNA-damage repair protein BRCA1 are believed to be responsible for 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer. The BRCA1 protein is a E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It contains an N-terminal zinc-finger domain. It also contains a BRCT C-terminal domain, an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.
- Taxonomy/Path:
- InterPro : BRCA1-associated / Breast cancer type 1 susceptibility protein (BRCA1)
SELECTED ORGANISM:
