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QuickView for Bromazepam (compound)


PubChem
Name: Bromazepam
PubChem Compound ID: 2441
Description: One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS.
Molecular formula: C14H10BrN3O
Molecular weight: 316.153 g/mol
Synonyms:
nchembio747-comp38; Lexomil; 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiazepin-2(1H)-one; Lexaurin; Lectopam (TN); Lekotam; D01245; KL 001; 2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridinyl)-; DEA No. 2748.
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DrugBank
Identification
Name: Bromazepam
Name (isomeric): DB01558
Drug Type: small molecule
Description: One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS.
Synonyms:
Bromazepamum [inn-latin]; 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiazepin-2(1H)-one; 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiaxepin-2(1H)-one
Brand: Calmepam, Compedium, Lectopam, Creosedin, Lexotanil, Gen-Bromazepam, Apo-Bromazepam, Ultramidol, Lexilium, Lexotan, Lekotam, Lexaurin, Nu-Bromazepam, Novo-bromazepam, Compendium, Durazanil, Somalium, Normoc, Lexomil
Category: Benzodiazepines, Anti-anxiety Agents, GABA Modulators, Hypnotics and Sedatives
CAS number: 1812-30-2
Pharmacology
Indication: For the short-term treatment of insomnia, short-term treatment of anxiety or panic attacks, if a benzodiazepine is required, and the alleviation of the symptoms of alcohol- and opiate-withdrawal.
Pharmacology:
Bromazepam is a lipophilic, long-acting benzodiazepine and with sedative, hypnotic, anxiolytic and skeletal muscle relaxant properties. It does not possess any antidepressant qualities. Bromazepam shares with other benzodiazepines the risk of abuse, misuse, psychological and/or physical dependence. According to many psychiatric experts Bromazepam h...
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Mechanism of Action: Bromazepam binds to the GABA receptor GABAA, causing a conformational change and increasing inhibitory effects of GABA. Other neurotransmitters are not influenced.
Absorption: Bioavailability is 84% following oral administration.
Biotransformation: Hepatically, via oxidative pathways (via an enzyme belonging to the Cytochrome P450 family of enzymes).
Half Life: 10-20 hours
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
ClozapineBromazepam may increase the adverse effects of clozapine. Consider alternate therapy or a reduction in the bromazepam dose. Monitor for respiratory depression and hypotension if concomitant therapy is initiated.
AtazanavirAtazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if atazanavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
IndinavirIndinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if indinavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
DiltiazemDiltiazem may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or a reductin in the bromazepam dose. Monitor for changes in the therapeutic and adverse effects of bromazepam if diltiazem is initiated, discontinued or dose changed.
FosamprenavirFosamprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if fosamprenavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
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Targets


Enzymes