Name: | Brompheniramine |
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PubChem Compound ID: | 5281067 |
Description: | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. |
Molecular formula: | C20H23BrN2O4 |
Molecular weight: | 435.312 g/mol |
Synonyms: |
Dimetane Extentabs; Gammistin; Pyridine, 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1); MLS000028423; Allent; Drauxin; 2-(p-Bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1); Lodrane LD; 8055-73-0; 86-22-6.
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Name: | Brompheniramine |
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Name (isomeric): | DB00835 |
Drug Type: | small molecule |
Description: | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. |
Synonyms: |
Brompheniramine Maleate
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Brand: | Veltane, Bromfed, Bromfenex, Dimetane |
Brand name mixture: | Dimetapp Oral Infant Cold and Fever Drops(Acetaminophen + Brompheniramine Maleate + Phenylephrine Hydrochloride), Dimetapp Extra Strength Dm Cough & Cold(Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride), Tantapp Elixir(Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)... show more » |
Category: | Histamine H1 Antagonists, Anti-Allergic Agents |
CAS number: | 86-22-6 |
Indication: | For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. |
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Pharmacology: |
Brompheniramine is an antihistaminergic medication of the propylamine class. It is a first-generation antihistamine. In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to ce...
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Mechanism of Action: |
Brompheniramine works by acting as an antagonist of the H1 histamine receptors. It also functions as a moderately effective anticholingeric agent, likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine. Its effects on the cholinergic system may include side-effects such as drowsiness, sedation, dry mouth, dry ...
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Absorption: | Antihistamines are well absorbed from the gastrointestinal tract after oral administration. |
Biotransformation: | Hepatic (cytochrome P-450 system), some renal. |
Toxicity: | Oral, rat: LD50 = 318 mg/kg. Signs of overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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Drug interaction: |
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