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QuickView for Brompheniramine (compound)


PubChem
Name: Brompheniramine
PubChem Compound ID: 5281067
Description: Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Molecular formula: C20H23BrN2O4
Molecular weight: 435.312 g/mol
Synonyms:
Dimetane Extentabs; Gammistin; Pyridine, 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1); MLS000028423; Allent; Drauxin; 2-(p-Bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1); Lodrane LD; 8055-73-0; 86-22-6.
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DrugBank
Identification
Name: Brompheniramine
Name (isomeric): DB00835
Drug Type: small molecule
Description: Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Synonyms:
Brompheniramine Maleate
Brand: Veltane, Bromfed, Bromfenex, Dimetane
Brand name mixture:
Dimetapp Oral Infant Cold and Fever Drops(Acetaminophen + Brompheniramine Maleate + Phenylephrine Hydrochloride), Dimetapp Extra Strength Dm Cough & Cold(Brompheniramine Maleate + Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride), Tantapp Elixir(Brompheniramine Maleate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)...
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Category: Histamine H1 Antagonists, Anti-Allergic Agents
CAS number: 86-22-6
Pharmacology
Indication: For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.
Pharmacology:
Brompheniramine is an antihistaminergic medication of the propylamine class. It is a first-generation antihistamine. In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to ce...
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Mechanism of Action:
Brompheniramine works by acting as an antagonist of the H1 histamine receptors. It also functions as a moderately effective anticholingeric agent, likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine. Its effects on the cholinergic system may include side-effects such as drowsiness, sedation, dry mouth, dry ...
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Absorption: Antihistamines are well absorbed from the gastrointestinal tract after oral administration.
Biotransformation: Hepatic (cytochrome P-450 system), some renal.
Toxicity: Oral, rat: LD50 = 318 mg/kg. Signs of overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid alcohol.
Take with food.
Drug interaction:
TrimethobenzamideTrimethobenzamide and Brompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
DonepezilPossible antagonism of action
TriprolidineTriprolidine and Brompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
RivastigminePossible antagonism of action
GalantaminePossible antagonism of action
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Enzymes