QuickView for Btf (gene)

Gene Symbol:

BCLAF1 Homo sapiens

Full name:

BCL2 associated transcription factor 1

Synonyms:

BTF, bK211L9.1, bcl-2-associated transcription factor 1, BCLAF1 and THRAP3 family member 1

Genomic Location:

Chr 6: 136619694-136652682

Description:

This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in c...

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This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  GCGSCMNTTT_UNKNOWN ,  STAT1_02 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  STAT1_03 ,  GGGYGTGNY_UNKNOWN ,  ACCAAAG_MIR9 ,  MGGAAGTG_GABP_B ,  STAT_01 ,  YGCGYRCGC_UNKNOWN ,  TTCYNRGAA_STAT5B_01 ,  STAT5A_01 ,  AAAGGAT_MIR501 ,  RCGCANGCGY_NRF1_Q6 ,  ACACTAC_MIR1423P

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-505

Cytogenetic Map:

6q23.3

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