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QuickView for Butabarbital (compound)

PubChem Substance
Name: secbutabarbital
PubChem Substance ID: 10029
Nilox; Butatab; Buticaps; Butisol Sodium; Sarisol; Butalan; Secbutabarbital; Butatal; Butabarb; Butabarbital.
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Name: secbutabarbital
Name (isomeric): DB00237
Drug Type: small molecule
Sodium Butabarbital; Butabarbital Sodium; Butrate; Secbutobarbitone; Secbubarbital; Secbutabarbital; Butabarbitone; Secbutobarbital
Brand: Unicelles, Sarisol No. 1, Butatab, Nilox, Butisol, Medarsed, Butatal, Butabarb, Butisol Sodium, Butalan, Sarisol, Buticaps
Category: Anti-anxiety Agents, Hypnotics and Sedatives, Barbiturates
CAS number: 125-40-6
Indication: For short-term treatment of insomnia and anxiety disorders
Pharmacology: Butabarbital, a barbiturate, is used for the treatment of short term insomnia. It belongs to a group of medicines called central nervous system (CNS) depressants that induce drowsiness and relieve tension or nervousness. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.
Mechanism of Action:
Butabarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GA...
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Route of elimination: Barbiturates are metabolized primarily by the hepatic microsomal enzyme system, and most metabolic products are excreted in the urine.
Toxicity: Signs of overdose include confusion (severe), decrease in or loss of reflexes, drowsiness (severe), fever, irritability (continuing), low body temperature, poor judgment, shortness of breath or slow or troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness (severe).
Affected organisms: Humans and other mammals
Drug interaction:
Ethinyl EstradiolThis product may cause a slight decrease of contraceptive effect
NortriptylineBarbiturates like butabarbital may increase the metabolism of tricyclic antidepressants like nortriptyline. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
GefitinibThe CYP3A4 inducer, butabarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
TriamcinoloneThe barbiturate, butabarbital, may decrease the effect of the corticosteroid, triamcinolone.
AcenocoumarolBarbiturates like butabarbital may increase the metabolism of Vitamin K Antagonists like acenocoumarol. onitor for decreased therapeutic effects of oral anticoagulants if a barbiturate is initiated/dose increased (anticoagulant dosage increases of 30% to 60% may be needed based on monitored PT), or increased effects if a barbiturate is discontinued/dose decreased. An increased frequency of PT monitoring should be considered for the period immediately following barbiturate initiation/dosage changes.
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