QuickView for Butethal (compound)

Butabarbitol; Butobarbitalum; Butobarbitural; Budorm; 5-Ethyl-5-N-butylbarbituric acid; Monodorm; Butobarbital; Butyl,5-ethylbarbituric acid; 5-Ethyl-5-butylbarbituric acid; Meonal.
show more »

Butabarbitol; Butobarbitalum; Butobarbitural; Budorm; 5-Ethyl-5-N-butylbarbituric acid; Monodorm; Butobarbital; Butyl,5-ethylbarbituric acid; 5-Ethyl-5-butylbarbituric acid; Meonal; 5-Butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione; Butobarbitone; Sonerile; Etoval; Longanoct; 5-Butyl-5-ethylbarbituric acid; Neonal; Hyperbutal; Butethal; Soneryl
show less «

Butabarbitol; Butobarbitural; Butobarbitalum; 5-Ethyl-5-N-butylbarbituric acid; Butobarbital; Butyl,5-ethylbarbituric acid; 5-Ethyl-5-butylbarbituric acid; 5-Butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Butyl-5-ethylbarbituric acid; Butobarbitone

Butethal binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor, increasing the duration of time for which the Cl^- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-s...
show more »

Butethal binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor, increasing the duration of time for which the Cl^- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.
show less «