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QuickView for C-FMS (gene)


Gene Symbol:
CSF1R Homo sapiens Homo sapiens
Full name:
colony stimulating factor 1 receptor
Synonyms:
C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, macrophage colony-stimulating factor 1 receptor, CD115 antigen, CSF-1 receptor, FMS proto-oncogene, McDonough feline sarcoma viral (v-fms) oncogene homolog, macrophage colony stimulating factor I receptor, proto-oncogene c-Fms
Genomic Location:
Chr 5: 149413051-149473128
Description:
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosph...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5q32





GO Molecular Function

cytokine binding | transmembrane receptor protein tyrosine kinase activity | transmembrane signaling receptor activity | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | signaling receptor activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | macrophage colony-stimulating factor receptor activity | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | protein homodimerization activity | protein phosphatase binding | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | brain development | cell morphogenesis | positive regulation of locomotion | response to cytokine | regulation of cell morphogenesis | neuron projection morphogenesis | ruffle organization | intracellular signal transduction | regulation of localization | mammary gland duct morphogenesis | morphogenesis of an epithelium | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | phosphatidylinositol metabolic process | myeloid cell differentiation | regulation of cell shape | negative regulation of cellular process | cell differentiation | defense response | nervous system development | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | positive regulation of protein secretion | phospholipid metabolic process | positive regulation of chemokine secretion | regulation of bone remodeling | cellular process | regulation of cell motility | cell projection morphogenesis | epithelial tube morphogenesis | negative regulation of signaling | neuron development | central nervous system neuron differentiation | immune system development | positive regulation of protein kinase activity | negative regulation of apoptotic process | axon guidance | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | forebrain neuron differentiation | tissue development | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | cellular lipid metabolic process | mammary gland morphogenesis | head development | regulation of peptide secretion | response to stimulus | cell morphogenesis involved in neuron differentiation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | gland morphogenesis | response to stress | neuron projection guidance | positive regulation of JAK-STAT cascade | regulation of cell proliferation | tube morphogenesis | phosphatidylinositol-mediated signaling | positive regulation of cytokine secretion | macrophage differentiation | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | hemopoiesis | protein modification process | regulation of actin cytoskeleton reorganization | regulation of peptide transport | macromolecule modification | positive regulation of peptide secretion | leukocyte differentiation | locomotion | regulation of protein tyrosine kinase activity | system development | nitrogen compound metabolic process | regulation of signal transduction | regulation of actin cytoskeleton organization | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | mammary gland development | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | monocyte differentiation | telencephalon development | osteoclast differentiation | axon development | positive regulation of secretion | myeloid leukocyte differentiation | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | protein autophosphorylation | regulation of nitrogen compound metabolic process | olfactory lobe development | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of STAT cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of cellular component movement | axonogenesis | positive regulation of cell migration | cellular response to cytokine stimulus | cell proliferation | regulation of cellular protein metabolic process | phosphorylation | inositol lipid-mediated signaling | positive regulation of chemokine production | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | olfactory bulb development | positive regulation of tyrosine phosphorylation of STAT protein | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | macrophage colony-stimulating factor receptor activity | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | glycerolipid metabolic process | positive regulation of transport | protein tyrosine kinase activity | positive regulation of molecular function | regulation of cytokine secretion | neuron differentiation | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | gland development | tissue morphogenesis | regulation of JAK-STAT cascade | regulation of kinase activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | cellular component maintenance | cell projection organization | metabolic process | negative regulation of programmed cell death | regulation of bone resorption | regulation of tissue remodeling | forebrain generation of neurons | regulation of secretion | immune response | protein kinase activity | neuron projection development | organic substance metabolic process | animal organ development | forebrain development | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | macrophage colony-stimulating factor signaling pathway | regulation of phosphate metabolic process | mammary gland epithelium development | positive regulation of cytokine production | positive regulation of MAPK cascade | positive regulation of protein transport | cell-cell junction maintenance | regulation of cell communication | negative regulation of signal transduction | signaling | cell development | positive regulation of phosphorylation | positive regulation of protein tyrosine kinase activity | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | regulation of developmental process | glycerophospholipid metabolic process | kinase activity | developmental process | cellular protein modification process | regulation of chemokine production | tube development | regulation of transport | negative regulation of cell proliferation | innate immune response | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | regulation of actin filament-based process | cellular response to macrophage colony-stimulating factor stimulus | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | chemotaxis | regulation of cellular component organization | regulation of cytoskeleton organization | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cell | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | protein-containing complex | nucleoplasm | plasma membrane | CSF1-CSF1R complex | integral component of plasma membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cell surface | intracellular | membrane | intrinsic component of plasma membrane