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QuickView for C3DR (gene)


Gene Symbol:
CR2 Homo sapiens Homo sapiens
Full name:
complement C3d receptor 2
Synonyms:
C3DR, CD21, CR, CVID7, SLEB9, complement receptor type 2, EBV receptor, complement component (3d/Epstein Barr virus) receptor 2, complement component 3d receptor 2
Genomic Location:
Chr 1: 205694293-205729863
Description:
This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 1
1q32.2





GO Molecular Function

transmembrane signaling receptor activity | nucleic acid binding | complement binding | DNA binding | signaling receptor activity | identical protein binding | organic cyclic compound binding | protein binding | protein homodimerization activity | protein dimerization activity | virus receptor activity | complement receptor activity | heterocyclic compound binding

GO Biological Process

positive regulation of immune response | adaptive immune response | immune response-regulating signaling pathway | complement activation | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | cell differentiation | immune response-activating cell surface receptor signaling pathway | defense response | B cell differentiation | cellular process | lymphocyte differentiation | immune system development | regulation of proteolysis | interspecies interaction between organisms | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | entry into host cell | viral life cycle | response to stimulus | positive regulation of immune system process | mononuclear cell proliferation | response to stress | regulation of humoral immune response | immune response-activating signal transduction | hemopoiesis | regulation of protein processing | leukocyte differentiation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | system development | nitrogen compound metabolic process | multicellular organism development | leukocyte mediated immunity | regulation of acute inflammatory response | regulation of gene expression | viral entry into host cell | regulation of nitrogen compound metabolic process | B cell activation | cell proliferation | leukocyte proliferation | protein activation cascade | regulation of complement activation | cell communication | humoral immune response | regulation of protein metabolic process | complement receptor mediated signaling pathway | viral process | lymphocyte activation | activation of immune response | protein metabolic process | anatomical structure development | cell surface receptor signaling pathway | complement activation, classical pathway | metabolic process | immune response | organic substance metabolic process | virus receptor activity | animal organ development | cell activation | lymphocyte proliferation | humoral immune response mediated by circulating immunoglobulin | complement receptor activity | signaling | B cell mediated immunity | developmental process | B cell proliferation | innate immune response | immunoglobulin mediated immune response | immune system process | hematopoietic or lymphoid organ development | regulation of inflammatory response | signal transduction | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

integral component of membrane | cell | intrinsic component of membrane | receptor complex | protein-containing complex | plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | membrane