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QuickView for C3aR (gene)


Gene Symbol:
C3AR1 Homo sapiens Homo sapiens
Full name:
complement C3a receptor 1
Synonyms:
AZ3B, C3AR, HNFAG09, C3a anaphylatoxin chemotactic receptor, complement component 3 receptor 1, complement component 3a receptor 1
Genomic Location:
Chr 12: 8102186-8110222
Description:
C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 12
12p13.31


Transcripts Names
NM_004054
NM_001326475
NM_001326477
Protein Names
O43771
Q92868
Q16581
A8K2H7



GO Molecular Function

transmembrane signaling receptor activity | G-protein coupled receptor activity | signaling receptor activity | complement component C3a receptor activity | complement receptor activity

GO Biological Process

positive regulation of immune response | regulation of leukocyte chemotaxis | positive regulation of locomotion | exocytosis | immune response-regulating signaling pathway | neutrophil activation | regulation of localization | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | positive regulation of developmental process | immune response-activating cell surface receptor signaling pathway | defense response | cellular chemical homeostasis | positive regulation of cellular component movement | cellular process | secretion | positive regulation of macrophage migration | leukocyte degranulation | regulation of cell motility | localization | cellular homeostasis | regulation of chemotaxis | regulation of proteolysis | regulation of angiogenesis | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | positive regulation of neutrophil migration | regulation of cytosolic calcium ion concentration | calcium ion homeostasis | regulation of neutrophil chemotaxis | G-protein coupled receptor activity | regulation of vasculature development | response to stimulus | neutrophil degranulation | positive regulation of immune system process | response to stress | leukocyte activation involved in immune response | regulation of humoral immune response | positive regulation of vascular endothelial growth factor production | secretion by cell | immune response-activating signal transduction | blood circulation | G-protein coupled receptor signaling pathway | regulation of protein processing | metal ion homeostasis | leukocyte mediated immunity | regulation of granulocyte chemotaxis | regulation of acute inflammatory response | regulation of gene expression | positive regulation of chemotaxis | cellular ion homeostasis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | vesicle-mediated transport | regulation of cellular component movement | positive regulation of cell migration | regulated exocytosis | regulation of complement activation | positive regulation of macrophage chemotaxis | cation homeostasis | regulation of leukocyte migration | cellular cation homeostasis | cell communication | positive regulation of leukocyte chemotaxis | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | neutrophil activation involved in immune response | cellular calcium ion homeostasis | homeostatic process | regulation of locomotion | complement receptor mediated signaling pathway | activation of immune response | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | cell surface receptor signaling pathway | regulation of neutrophil migration | complement component C3a receptor activity | positive regulation of neutrophil chemotaxis | chemical homeostasis | immune response | positive regulation of leukocyte migration | ion homeostasis | phospholipase C-activating G-protein coupled receptor signaling pathway | positive regulation of cytokine production | cell activation | complement receptor activity | signaling | regulation of cytokine production | regulation of developmental process | neutrophil mediated immunity | positive regulation of granulocyte chemotaxis | cellular metal ion homeostasis | regulation of vascular endothelial growth factor production | regulation of macrophage chemotaxis | immune system process | positive regulation of cell motility | regulation of inflammatory response | divalent inorganic cation homeostasis | positive regulation of angiogenesis | signal transduction | multicellular organismal process

GO Cellular Component

secretory granule | integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | secretory granule membrane | secretory vesicle | endomembrane system | plasma membrane | azurophil granule membrane | vacuole | vesicle | specific granule | lytic vacuole | integral component of plasma membrane | membrane-bounded organelle | organelle | vesicle membrane | lysosome | cell periphery | azurophil granule | intracellular vesicle | intracellular | specific granule membrane | lysosomal membrane | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane | vacuolar membrane