QuickView for C5a (gene)

Gene Symbol:

Hc Mus musculus

Full name:

hemolytic complement

Synonyms:

C5, C5a, He, complement C5

Genomic Location:

Chr 2: 34838851-34916916

Description:

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin an...

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This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

YY1_01 ,  BRN2_01 ,  PAX4_02 ,  POU6F1_01 ,  CRX_Q4 ,  HNF3ALPHA_Q6 ,  HNF1_Q6 ,  GCTTGAA_MIR498 ,  TGACATY_UNKNOWN ,  TTANTCA_UNKNOWN ,  WTGAAAT_UNKNOWN ,  TAATTA_CHX10_01 ,  TGTTTGY_HNF3_Q6

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