QuickView for C7;jsessionid=64EE3FB6B9C8693E79AC5B369EF2B336 (gene)

Gene Symbol:

C7 Homo sapiens

Full name:

complement C7

Synonyms:

complement component C7, complement component 7

Genomic Location:

Chr 5: 40945356-41018798

Description:

This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs t...

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This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GCANCTGNY_MYOD_Q6 ,  RGAANNTTC_HSF1_01 ,  GGATTA_PITX2_Q2 ,  STAT5B_01 ,  HAND1E47_01 ,  GTGTCAA_MIR514 ,  TTCYNRGAA_STAT5B_01 ,  STAT5A_01 ,  CAGCTG_AP4_Q5

Cytogenetic Map:

5p13.1

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