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QuickView for C8B (gene)


Gene Symbol:
C8B Homo sapiens Homo sapiens
Full name:
complement C8 beta chain
Synonyms:
C82, complement component C8 beta chain, complement component 8 subunit beta, complement component 8, beta polypeptide
Genomic Location:
Chr 1: 57167471-57204276
Description:
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein me...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 1
1p32.2





GO Molecular Function

protein-containing complex binding

GO Biological Process

positive regulation of immune response | adaptive immune response | complement activation | regulation of immune system process | defense response | cellular process | regulation of proteolysis | regulation of immune response | regulation of metabolic process | response to stimulus | positive regulation of immune system process | response to stress | regulation of humoral immune response | regulation of protein processing | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | nitrogen compound metabolic process | leukocyte mediated immunity | regulation of acute inflammatory response | regulation of gene expression | complement activation, alternative pathway | regulation of nitrogen compound metabolic process | protein activation cascade | regulation of complement activation | humoral immune response | regulation of protein metabolic process | activation of immune response | protein metabolic process | complement activation, classical pathway | metabolic process | immune response | organic substance metabolic process | humoral immune response mediated by circulating immunoglobulin | B cell mediated immunity | innate immune response | cytolysis | immunoglobulin mediated immune response | immune system process | regulation of inflammatory response | macromolecule metabolic process

GO Cellular Component

integral component of membrane | cell | plasma membrane protein complex | intrinsic component of membrane | protein-containing complex | plasma membrane | vesicle | extracellular exosome | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | pore complex | membrane attack complex | membrane | intrinsic component of plasma membrane