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QuickView for CA-II (gene)


Gene Symbol:
CA2 Homo sapiens Homo sapiens
Full name:
carbonic anhydrase 2
Synonyms:
CA-II, CAC, CAII, Car2, HEL-76, HEL-S-282, carbonic anhydrase 2, carbonate dehydratase II, carbonic anhydrase B, carbonic anhydrase C, carbonic anhydrase II, carbonic dehydratase, epididymis luminal protein 76, epididymis secretory protein Li 282
Genomic Location:
Chr 8: 86563383-86580973
Description:
The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 8
8q21.2


Transcripts Names
NM_000067
NM_001293675
Protein Names
B2R7G8
V9HW21
Q96ET9
Q6FI12
P00918



GO Molecular Function

cation binding | arylesterase activity | carboxylic ester hydrolase activity | hydrolase activity | carbonate dehydratase activity | hydro-lyase activity | lyase activity | catalytic activity | hydrolase activity, acting on ester bonds | ion binding | protein binding | zinc ion binding | transition metal ion binding | metal ion binding

GO Biological Process

regulation of localization | positive regulation of cellular pH reduction | morphogenesis of an epithelium | establishment of localization | regulation of immune system process | response to hormone | positive regulation of developmental process | response to metal ion | response to drug | cellular chemical homeostasis | regulation of bone remodeling | cellular process | secretion | localization | cellular homeostasis | positive regulation of synaptic transmission | odontogenesis | anion transport | regulation of myeloid cell differentiation | response to inorganic substance | response to peptide hormone | tissue development | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | regulation of cellular process | epithelium development | cellular response to organonitrogen compound | positive regulation of dipeptide transmembrane transport | urogenital system development | response to stimulus | regulation of chloride transport | positive regulation of osteoclast differentiation | positive regulation of immune system process | response to stress | carbon dioxide transport | response to peptide | G-protein coupled receptor signaling pathway | regulation of peptide transport | modulation of chemical synaptic transmission | kidney development | response to pH | response to nitrogen compound | cellular response to hormone stimulus | system development | multicellular organism development | regulation of synaptic transmission, GABAergic | cellular response to peptide hormone stimulus | organic substance transport | cellular response to stress | response to lipid | cellular response to peptide | cellular ion homeostasis | animal organ morphogenesis | cellular response to fluid shear stress | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | bicarbonate transport | organic anion transport | cation homeostasis | cellular response to angiotensin | response to estrogen | angiotensin-activated signaling pathway | cellular cation homeostasis | cell communication | regulation of intracellular pH | odontogenesis of dentin-containing tooth | homeostatic process | response to zinc ion | positive regulation of synaptic transmission, GABAergic | renal system development | positive regulation of transport | response to angiotensin | response to organic substance | tissue morphogenesis | regulation of hemopoiesis | regulation of pH | anatomical structure development | regulation of bone resorption | regulation of tissue remodeling | chemical homeostasis | animal organ development | ion homeostasis | regulation of cellular pH | drug transport | regulation of dipeptide transport | regulation of osteoclast differentiation | response to fluid shear stress | regulation of cell communication | signaling | response to organic cyclic compound | cellular monovalent inorganic cation homeostasis | anatomical structure morphogenesis | positive regulation of tissue remodeling | regulation of developmental process | regulation of ion transport | developmental process | regulation of transport | positive regulation of bone resorption | response to organonitrogen compound | regulation of anion transport | ion transport | positive regulation of myeloid leukocyte differentiation | cellular response to organic substance | response to steroid hormone | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

neuron projection | actin-based cell projection | cell | cytoplasm | apical part of cell | cell projection | plasma membrane | vesicle | extracellular exosome | extracellular region | microvillus | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | axon | basolateral plasma membrane | cytosol | intracellular | myelin sheath | membrane