QuickView for CACH2 (gene)

Gene Symbol:

CACNA1C Homo sapiens

Full name:

calcium voltage-gated channel subunit alpha1 C

Synonyms:

CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS, voltage-dependent L-type calcium channel subunit alpha-1C, DHPR, alpha-1 subunit, calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit, calcium channel, voltage-dependent, L type, alpha 1C subunit, voltage-dependent L-type Ca2+ channel alpha 1 subunit, voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*

Genomic Location:

Chr 12: 2032725-2677376

Description:

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/d...

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This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CTTGTAT_MIR381 ,  POU6F1_01 ,  TTTGCAC_MIR19A_MIR19B ,  OCT1_B ,  FOXJ2_02 ,  OCT1_04 ,  OCT1_01 ,  NKX3A_01 ,  FOXD3_01 ,  EVI1_04 ,  YNTTTNNNANGCARM_UNKNOWN ,  TACTTGA_MIR26A_MIR26B ,  IRF1_Q6 ,  NKX22_01 ,  GGGAGGRR_MAZ_Q6 ,  YAATNRNNNYNATT_UNKNOWN ,  CATGTAA_MIR496 ,  CDX2_Q5 ,  NF1_Q6 ,  ATGTTTC_MIR494 ,  GTGCCAA_MIR96 ,  NKX25_02 ,  PAX6_01 ,  TGCCAAR_NF1_Q6 ,  NF1_Q6_01 ,  GATA1_02 ,  PTF1BETA_Q6 ,  OCT1_02 ,  ATATGCA_MIR448 ,  PIT1_Q6 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  IK2_01 ,  ICSBP_Q6 ,  CDC5_01 ,  AAACCAC_MIR140 ,  BRN2_01 ,  TCF1P_Q6 ,  CAATGCA_MIR33

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-505

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Cytogenetic Map:

12p13.33

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