QuickView for CACNA1B (gene)

Gene Symbol:

CACNA1B Homo sapiens

Full name:

calcium voltage-gated channel subunit alpha1 B

Synonyms:

BIII, CACNL1A5, CACNN, Cav2.2, DYT23, voltage-dependent N-type calcium channel subunit alpha-1B, Cav2.2 voltage-gated Ca2+ channel, brain calcium channel III, calcium channel alpha12.2 subunit, calcium channel, L type, alpha-1 polypeptide, calcium channel, voltage-dependent, L type, alpha 1B subunit, calcium channel, voltage-dependent, N type, alpha 1B subunit, voltage-gated calcium channel alpha subunit Cav2.2, voltage-gated calcium channel subunit alpha Cav2.2

Genomic Location:

Chr 9: 139892062-140136449

Description:

The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin...

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The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  SRF_Q6 ,  GGGYGTGNY_UNKNOWN ,  SP1_Q4_01 ,  EGR_Q6 ,  CAGNWMCNNNGAC_UNKNOWN ,  TGCTGAY_UNKNOWN ,  SRF_Q4 ,  AHR_Q5 ,  SP1_Q6 ,  SRF_Q5_01 ,  RCGCANGCGY_NRF1_Q6 ,  SRF_C

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Cytogenetic Map:

9q34.3

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