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QuickView for CACNA1D (gene)


Gene Symbol:
Cacna1d Mus musculus Mus musculus
Full name:
calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms:
8430418G19Rik, C79217, Cach3, Cacn4, Cacnl1a2, Cav1.3, Cchl1a, Cchl1a2, D-LTCC, voltage-dependent L-type calcium channel subunit alpha-1D, Cav1.3alpha1, alpha 1 E, calcium channel, L type, alpha-1 polypeptide, voltage-gated calcium channel subunit alpha Cav1.3
Genomic Location:
Chr 14: 30853125-31304342
Description:
This gene encodes a pore-forming subunit of the L-type, voltage-activated calcium channel family. These channels have been found to play a role in heart and smooth muscle contraction and in the transmission of auditory information. Homozygous knockout mice for this gene exhibit deafness and heart defects. These channels have also been linked to mit...
Orthologs:
Homo sapiens Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Danio rerio Bos taurus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

high voltage-gated calcium channel activity | voltage-gated ion channel activity | cation binding | passive transmembrane transporter activity | transmembrane transporter activity | ion gated channel activity | alpha-actinin binding | voltage-gated calcium channel activity | protein domain specific binding | cytoskeletal protein binding | cation transmembrane transporter activity | transporter activity | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | ion binding | ankyrin binding | protein binding | metal ion transmembrane transporter activity | voltage-gated cation channel activity | cation channel activity | voltage-gated calcium channel activity involved SA node cell action potential | inorganic cation transmembrane transporter activity | PDZ domain binding | voltage-gated channel activity | channel activity | calcium channel activity | voltage-gated calcium channel activity involved in cardiac muscle cell action potential | actinin binding | metal ion binding | ion channel activity | substrate-specific channel activity

GO Biological Process

positive regulation of insulin secretion involved in cellular response to glucose stimulus | heart process | actin filament-based process | regulation of cellular localization | intracellular signal transduction | regulation of localization | positive regulation of DNA-binding transcription factor activity | high voltage-gated calcium channel activity | establishment of localization | membrane depolarization during action potential | voltage-gated ion channel activity | regulation of peptide hormone secretion | positive regulation of protein secretion | sensory perception of mechanical stimulus | calcium ion import | cellular process | localization | passive transmembrane transporter activity | metal ion transport | actin filament-based movement | regulation of cellular process | membrane depolarization during cardiac muscle cell action potential | regulation of metabolic process | transmembrane transporter activity | heart contraction | actin-mediated cell contraction | regulation of peptide secretion | regulation of atrial cardiac muscle cell membrane repolarization | muscle contraction | response to stimulus | ion gated channel activity | regulation of insulin secretion | regulation of blood circulation | regulation of heart rate | divalent metal ion transport | positive regulation of hormone secretion | regulation of protein transport | blood circulation | G-protein coupled receptor signaling pathway | regulation of peptide transport | cell-cell signaling | regulation of nucleic acid-templated transcription | regulation of potassium ion transmembrane transport | positive regulation of peptide secretion | regulation of membrane potential | voltage-gated calcium channel activity | calcium ion transmembrane transport | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | regulation of insulin secretion involved in cellular response to glucose stimulus | regulation of hormone levels | ion transmembrane transport | regulation of hormone secretion | SA node cell to atrial cardiac muscle cell communication | regulation of gene expression | positive regulation of secretion | nervous system process | cation transmembrane transporter activity | regulation of nitrogen compound metabolic process | cardiac muscle cell action potential involved in contraction | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | second-messenger-mediated signaling | SA node cell action potential | cell-cell signaling involved in cardiac conduction | regulation of heart contraction | regulation of potassium ion transmembrane transporter activity | cell communication | regulation of cellular metabolic process | membrane depolarization during SA node cell action potential | cardiac muscle cell contraction | sensory perception of sound | positive regulation of establishment of protein localization | regulation of RNA metabolic process | positive regulation of transport | striated muscle contraction | positive regulation of peptide hormone secretion | regulation of potassium ion transport | positive regulation of molecular function | calcium-mediated signaling | cation transmembrane transport | regulation of establishment of protein localization | regulation of heart rate by cardiac conduction | positive regulation of insulin secretion | metal ion transmembrane transporter activity | regulation of DNA-binding transcription factor activity | voltage-gated cation channel activity | regulation of RNA biosynthetic process | cell communication involved in cardiac conduction | calcium ion transport | regulation of secretion | membrane depolarization | positive regulation of ion transport | regulation of protein secretion | SA node cell to atrial cardiac muscle cell signaling | inorganic cation transmembrane transport | regulation of ion transmembrane transport | positive regulation of protein transport | cation channel activity | sensory perception | positive regulation of CREB transcription factor activity | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | voltage-gated calcium channel activity involved SA node cell action potential | transmembrane transport | action potential | signaling | inorganic cation transmembrane transporter activity | regulation of transcription, DNA-templated | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | voltage-gated channel activity | cation transport | channel activity | regulation of ion transport | calcium channel activity | regulation of calcium ion transport | voltage-gated calcium channel activity involved in cardiac muscle cell action potential | regulation of transport | cardiac muscle cell action potential | ion channel activity | ion transport | cardiac muscle contraction | regulation of protein localization | substrate-specific channel activity | regulation of membrane repolarization | positive regulation of calcium ion transport | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | cardiac conduction | multicellular organismal process

GO Cellular Component

supramolecular fiber | integral component of membrane | dendrite | intracellular membrane-bounded organelle | sarcolemma | apical plasma membrane | neuron projection | somatodendritic compartment | cell projection membrane | sarcomere | voltage-gated calcium channel complex | cell body | cell | neuronal cell body | plasma membrane protein complex | intrinsic component of membrane | myofibril | cytoplasm | intracellular organelle | dendritic tree | contractile fiber | leading edge membrane | apical part of cell | protein-containing complex | cell projection | plasma membrane | cell leading edge | integral component of plasma membrane | T-tubule | calcium channel complex | dendrite membrane | membrane-bounded organelle | nucleus | organelle | I band | cell periphery | L-type voltage-gated calcium channel complex | transmembrane transporter complex | cation channel complex | ion channel complex | Z disc | intracellular | membrane | supramolecular complex | neuron projection membrane | intrinsic component of plasma membrane