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QuickView for CACNA2D1 (gene)


Gene Symbol:
CACNA2D1 Homo sapiens Homo sapiens
Full name:
calcium voltage-gated channel auxiliary subunit alpha2delta 1
Synonyms:
CACNA2, CACNL2A, CCHL2A, LINC01112, lncRNA-N3, voltage-dependent calcium channel subunit alpha-2/delta-1, calcium channel, L type, alpha 2 polypeptide, calcium channel, voltage-dependent, alpha 2/delta subunit 1, dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit, voltage-gated calcium channel subunit alpha-2/delta-1
Genomic Location:
Chr 7: 81417354-81910967
Description:
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and shor...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Pan troglodytes Danio rerio Canis lupus familiaris Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 7
7q21.11





GO Molecular Function

voltage-gated ion channel activity | cation binding | passive transmembrane transporter activity | transmembrane transporter activity | ion gated channel activity | voltage-gated calcium channel activity | cation transmembrane transporter activity | transporter activity | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | ion binding | voltage-gated calcium channel activity involved in bundle of His cell action potential | metal ion transmembrane transporter activity | voltage-gated cation channel activity | cation channel activity | inorganic cation transmembrane transporter activity | voltage-gated channel activity | channel activity | calcium channel activity | voltage-gated calcium channel activity involved in cardiac muscle cell action potential | metal ion binding | ion channel activity | substrate-specific channel activity

GO Biological Process

regulation of ventricular cardiac muscle cell membrane repolarization | heart process | actin filament-based process | positive regulation of ion transmembrane transporter activity | calcium ion transmembrane import into cytosol | cytosolic calcium ion transport | regulation of localization | positive regulation of voltage-gated calcium channel activity | establishment of localization | calcium ion import into cytosol | membrane depolarization during action potential | cellular chemical homeostasis | positive regulation of cation channel activity | voltage-gated ion channel activity | calcium ion import | cellular process | calcium ion import across plasma membrane | localization | cellular homeostasis | passive transmembrane transporter activity | metal ion transport | calcium ion transmembrane transport via high voltage-gated calcium channel | establishment of localization in cell | actin filament-based movement | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | membrane depolarization during cardiac muscle cell action potential | regulation of cytosolic calcium ion concentration | transmembrane transporter activity | bundle of His cell action potential | heart contraction | cellular response to organonitrogen compound | actin-mediated cell contraction | calcium ion homeostasis | calcium ion transport into cytosol | muscle contraction | response to stimulus | ion gated channel activity | positive regulation of cation transmembrane transport | regulation of blood circulation | response to peptide | regulation of high voltage-gated calcium channel activity | regulation of heart rate | cellular localization | divalent metal ion transport | blood circulation | cell-cell signaling | metal ion homeostasis | regulation of membrane potential | voltage-gated calcium channel activity | response to nitrogen compound | positive regulation of calcium ion transmembrane transport | calcium ion transmembrane transport | ion transmembrane transport | cellular response to peptide | cation transmembrane transporter activity | cellular ion homeostasis | positive regulation of ion transmembrane transport | positive regulation of cytosolic calcium ion concentration | cardiac muscle cell action potential involved in contraction | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | bundle of His cell to Purkinje myocyte communication | regulation of calcium ion transmembrane transport | cell-cell signaling involved in cardiac conduction | regulation of voltage-gated calcium channel activity | regulation of heart contraction | cation homeostasis | cellular cation homeostasis | cell communication | cardiac muscle cell contraction | positive regulation of transporter activity | cellular response to amyloid-beta | cellular calcium ion homeostasis | homeostatic process | positive regulation of transport | striated muscle contraction | positive regulation of molecular function | cation transmembrane transport | regulation of heart rate by cardiac conduction | response to organic substance | voltage-gated calcium channel activity involved in bundle of His cell action potential | import into cell | metal ion transmembrane transporter activity | voltage-gated cation channel activity | cell communication involved in cardiac conduction | chemical homeostasis | calcium ion transport | membrane depolarization | positive regulation of ion transport | ion homeostasis | inorganic cation transmembrane transport | regulation of ion transmembrane transport | cation channel activity | regulation of action potential | transmembrane transport | action potential | signaling | inorganic cation transmembrane transporter activity | response to amyloid-beta | positive regulation of calcium ion transmembrane transporter activity | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | voltage-gated channel activity | cation transport | channel activity | regulation of ion transport | calcium channel activity | regulation of calcium ion transport | inorganic cation import across plasma membrane | voltage-gated calcium channel activity involved in cardiac muscle cell action potential | regulation of transport | cardiac muscle cell action potential | regulation of cation channel activity | response to organonitrogen compound | cellular metal ion homeostasis | membrane depolarization during bundle of His cell action potential | regulation of membrane repolarization during action potential | ion channel activity | regulation of calcium ion transmembrane transporter activity | ion transport | cardiac muscle contraction | cellular response to organic substance | divalent inorganic cation homeostasis | substrate-specific channel activity | regulation of membrane repolarization | positive regulation of calcium ion transport | muscle system process | cardiac conduction | positive regulation of high voltage-gated calcium channel activity | multicellular organismal process

GO Cellular Component

integral component of membrane | sarcoplasmic reticulum | intracellular membrane-bounded organelle | sarcolemma | voltage-gated calcium channel complex | cell | plasma membrane protein complex | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | protein-containing complex | endomembrane system | plasma membrane | vesicle | extracellular exosome | T-tubule | calcium channel complex | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | sarcoplasm | extracellular space | cell periphery | L-type voltage-gated calcium channel complex | transmembrane transporter complex | cation channel complex | ion channel complex | intracellular | membrane