QuickView for CACNA2D3 (gene)

Gene Symbol:

CACNA2D3 Homo sapiens

Full name:

calcium voltage-gated channel auxiliary subunit alpha2delta 3

Synonyms:

HSA272268, voltage-dependent calcium channel subunit alpha-2/delta-3, calcium channel alpha2-delta3 subunit, calcium channel, voltage-dependent, alpha 2/delta 3 subunit, calcium channel, voltage-dependent, alpha 2/delta subunit 3, voltage-gated calcium channel subunit alpha-2/delta-3

Genomic Location:

Chr 3: 54131733-55083624

Description:

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these su...

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This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NKX25_01 ,  TGGAAA_NFAT_Q4_01 ,  POU6F1_01 ,  FREAC7_01 ,  GATA1_03 ,  MZF1_01 ,  RSRFC4_01 ,  EFC_Q6 ,  SREBP1_02 ,  GATA_Q6 ,  YTATTTTNR_MEF2_02 ,  GCANCTGNY_MYOD_Q6 ,  RSRFC4_Q2 ,  HP1SITEFACTOR_Q6 ,  STAT6_01 ,  TAAYNRNNTCC_UNKNOWN ,  GATAAGR_GATA_C ,  TTF1_Q6 ,  PBX1_01 ,  CTAWWWATA_RSRFC4_Q2 ,  RFX1_01 ,  ACTGTGA_MIR27A_MIR27B ,  OSF2_Q6 ,  CDP_01 ,  MEF2_02 ,  CEBPDELTA_Q6 ,  CDP_02 ,  GCTTGAA_MIR498 ,  PAX4_02 ,  TITF1_Q3 ,  CAGGTA_AREB6_01 ,  MEF2_01 ,  RP58_01 ,  CEBP_01 ,  CAGGTG_E12_Q6 ,  YY1_01 ,  TST1_01 ,  NKX62_Q2 ,  HNF4_Q6 ,  STAT5A_03 ,  PITX2_Q2 ,  LMO2COM_02 ,  GATA6_01 ,  OCT1_03 ,  CTTTAAR_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  TGTTTGY_HNF3_Q6 ,  GATA1_02 ,  HMEF2_Q6 ,  HLF_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  CEBP_C ,  AAAYRNCTG_UNKNOWN ,  RYTGCNNRGNAAC_MIF1_01 ,  AFP1_Q6 ,  GATA1_05 ,  IRF7_01 ,  PAX_Q6 ,  T3R_Q6 ,  TCCATTKW_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  YWATTWNNRGCT_UNKNOWN ,  CAGCTG_AP4_Q5 ,  MMEF2_Q6 ,  AACTTT_UNKNOWN ,  GGCAGTG_MIR3243P ,  COREBINDINGFACTOR_Q6 ,  HNF6_Q6 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-324-3p

Cytogenetic Map:

3p21.1-p14.3

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