QuickView for CACNB2;jsessionid=DBD61CA45A8F05E6B5DA177159229349 (gene)

Gene Symbol:

CACNB2 Homo sapiens

Full name:

calcium voltage-gated channel auxiliary subunit beta 2

Synonyms:

CACNLB2, CAVB2, MYSB, voltage-dependent L-type calcium channel subunit beta-2, CAB2, calcium channel voltage-dependent subunit beta 2, calcium channel, voltage-dependent, beta 2 subunit, lambert-Eaton myasthenic syndrome antigen B, myasthenic (Lambert-Eaton) syndrome antigen B

Genomic Location:

Chr 10: 18469612-18870694

Description:

This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced...

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This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  RTAAACA_FREAC2_01 ,  CEBPA_01 ,  MYOD_01 ,  P53_DECAMER_Q2 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  SMAD3_Q6 ,  GCANCTGNY_MYOD_Q6 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GTACTGT_MIR101 ,  GCCATNTTG_YY1_Q6 ,  TGACCTY_ERR1_Q2 ,  HEB_Q6 ,  ACTGTGA_MIR27A_MIR27B ,  GGGAGGRR_MAZ_Q6 ,  HNF4_01 ,  RYTGCNWTGGNR_UNKNOWN ,  LEF1_Q2 ,  TGCAAAC_MIR452 ,  YY1_Q6 ,  CAGGTA_AREB6_01 ,  RP58_01 ,  P53_02 ,  CAGGTG_E12_Q6 ,  AP4_Q6 ,  AP4_01 ,  YY1_01 ,  AGTCAGC_MIR345 ,  HNF4_Q6 ,  TGCCTTA_MIR124A ,  CEBPB_02 ,  GATA6_01 ,  HMX1_01 ,  TGCCAAR_NF1_Q6 ,  GATA1_02 ,  NRF2_Q4 ,  RORA1_01 ,  GFI1_01 ,  MYB_Q6 ,  CHOP_01 ,  AAAYRNCTG_UNKNOWN ,  HEN1_02 ,  CREB_Q2 ,  CTGCAGY_UNKNOWN ,  CAGCTG_AP4_Q5 ,  SMAD_Q6 ,  P300_01 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  ERR1_Q2 ,  TGACCTTG_SF1_Q6 ,  CREB_Q2_01 ,  CTGRYYYNATT_UNKNOWN ,  SF1_Q6 ,  STAT5A_02 ,  LBP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-151 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-499 ,  Predicted Gene Targets for miR-543 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

10p12.33-p12.31

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