QuickView for CALCR (gene)
- Gene Symbol:
- CALCR
Homo sapiens - Full name:
- calcitonin receptor
- Synonyms:
- CRT, CT-R, CTR, CTR1, calcitonin receptor
- Genomic Location:
- Chr 7: 92891735-93041686
- Description:
-
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variation...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-190 , Predicted Gene Targets for miR-141 , Predicted Gene Targets for miR-22 , Predicted Gene Targets for miR-23 , Predicted Gene Targets for miR-24 , Predicted Gene Targets for miR-299 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-323 , Predicted Gene Targets for miR-34 , Predicted Gene Targets for miR-34b
- Cytogenetic Map:
-
7q21.3
GO Molecular Function
peptide binding | peptide hormone binding | transmembrane signaling receptor activity | G-protein coupled receptor activity | calcitonin gene-related peptide receptor activity | amide binding | signaling receptor activity | amylin receptor activity | hormone binding | protein binding | calcitonin receptor activity | peptide receptor activity | G-protein coupled peptide receptor activity | drug binding | calcitonin binding
GO Biological Process
negative regulation of signaling receptor activity | regulation of ERK1 and ERK2 cascade | regulation of cellular localization | intracellular signal transduction | regulation of localization | positive regulation of calcium ion import across plasma membrane | response to hormone | cellular chemical homeostasis | positive regulation of phosphate metabolic process | cellular process | cellular homeostasis | positive regulation of protein kinase A signaling | positive regulation of peptidyl-serine phosphorylation | positive regulation of nitrogen compound metabolic process | regulation of protein kinase B signaling | regulation of cellular process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | positive regulation of cellular protein metabolic process | calcium ion homeostasis | G-protein coupled receptor activity | response to stimulus | positive regulation of protein metabolic process | positive regulation of cation transmembrane transport | G-protein coupled receptor signaling pathway | calcitonin gene-related peptide receptor activity | metal ion homeostasis | regulation of calcium ion transport into cytosol | cross-receptor inhibition within G-protein coupled receptor heterodimer | regulation of signal transduction | positive regulation of calcium ion transmembrane transport | regulation of MAPK cascade | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of phosphorylation | amylin receptor signaling pathway | positive regulation of calcium ion import | regulation of gene expression | response to lipid | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | positive regulation of ion transmembrane transport | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | response to corticosteroid | second-messenger-mediated signaling | regulation of cellular protein metabolic process | regulation of calcium ion transmembrane transport | cation homeostasis | amylin receptor activity | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | cyclic-nucleotide-mediated signaling | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | positive regulation of transport | regulation of signaling receptor activity | activation of adenylate cyclase activity | positive regulation of protein modification process | response to organic substance | cAMP-mediated signaling | regulation of intracellular signal transduction | calcitonin receptor activity | cell surface receptor signaling pathway | regulation of calcium ion import across plasma membrane | chemical homeostasis | positive regulation of cell death | positive regulation of ion transport | positive regulation of ERK1 and ERK2 cascade | ion homeostasis | regulation of phosphate metabolic process | regulation of ion transmembrane transport | positive regulation of MAPK cascade | regulation of protein kinase A signaling | regulation of peptidyl-serine phosphorylation | regulation of calcium ion import | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of molecular function | signaling | G-protein coupled peptide receptor activity | response to organic cyclic compound | positive regulation of phosphorylation | positive regulation of calcium ion transport into cytosol | regulation of ion transport | regulation of G-protein coupled receptor protein signaling pathway | regulation of calcium ion transport | regulation of transport | cellular metal ion homeostasis | positive regulation of metabolic process | regulation of cell death | response to steroid hormone | divalent inorganic cation homeostasis | positive regulation of calcium ion transport | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | response to glucocorticoid | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | neuron projection | cell | plasma membrane protein complex | intrinsic component of membrane | G-protein coupled receptor complex | receptor complex | protein-containing complex | cell projection | plasma membrane | integral component of plasma membrane | cell periphery | axon | intracellular | amylin receptor complex | membrane | intrinsic component of plasma membrane
