QuickView for CALML2 (gene)
- Gene Symbol:
- CALM1
Homo sapiens - Full name:
- calmodulin 1
- Synonyms:
- CALML2, CAMI, CPVT4, DD132, LQT14, PHKD, caM, calmodulin-1, calmodulin, calmodulin 1 (phosphorylase kinase, delta), phosphorylase kinase subunit delta, phosphorylase kinase, delta subunit, prepro-calmodulin 1
- Genomic Location:
- Chr 14: 89933126-89944363
- Description:
-
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for let-7 , Predicted Gene Targets for miR-1 , Predicted Gene Targets for miR-142-3p , Predicted Gene Targets for miR-142-5p , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-19 , Predicted Gene Targets for miR-214 , Predicted Gene Targets for miR-409-5p , Predicted Gene Targets for miR-410
- Cytogenetic Map:
-
14q32.11
GO Molecular Function
protein kinase activator activity | phosphatidylinositol 3-kinase binding | protein serine/threonine kinase activator activity | guanyl-nucleotide exchange factor activity | kinase binding | enzyme activator activity | protein kinase regulator activity | GTPase binding | protein phosphatase activator activity | channel regulator activity | cation binding | adenylate cyclase binding | passive transmembrane transporter activity | kinase regulator activity | protein kinase binding | G-protein coupled glutamate receptor binding | enzyme binding | disordered domain specific binding | transmembrane transporter activity | ligand-gated ion channel activity | ion gated channel activity | ion channel inhibitor activity | signaling receptor binding | phosphatase activator activity | Ras GTPase binding | molecular function regulator | catalytic activity | ion channel binding | protein domain specific binding | protein N-terminus binding | channel inhibitor activity | cytoskeletal protein binding | adenylate cyclase activator activity | transporter activity | calcium-dependent protein binding | ion transmembrane transporter activity | ion binding | protein binding | calcium channel regulator activity | N-terminal myristoylation domain binding | kinase activator activity | transferase activity, transferring phosphorus-containing groups | nitric-oxide synthase binding | G-protein coupled receptor binding | phosphotransferase activity, alcohol group as acceptor | nitric-oxide synthase regulator activity | Ras guanyl-nucleotide exchange factor activity | protein phosphatase regulator activity | transferase activity | small GTPase binding | calcium ion binding | titin binding | calcium channel inhibitor activity | enzyme regulator activity | channel activity | kinase activity | type 3 metabotropic glutamate receptor binding | inositol-1,4,5-trisphosphate 3-kinase activity | metal ion binding | ion channel activity | substrate-specific channel activity | glutamate receptor binding | phosphatase regulator activity
GO Biological Process
positive regulation of release of sequestered calcium ion into cytosol | negative regulation of phosphorylation | brain development | regulation of muscle system process | regulation of cell cycle process | protein kinase activator activity | regulation of dephosphorylation | protein serine/threonine kinase activator activity | guanyl-nucleotide exchange factor activity | exocytosis | detection of stimulus | positive regulation of ion transmembrane transporter activity | immune response-regulating signaling pathway | regulation of cellular localization | intracellular signal transduction | enzyme activator activity | protein localization to mitochondrion | regulation of localization | protein kinase regulator activity | positive regulation of peptidyl-threonine phosphorylation | spindle pole body organization | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | response to hormone | positive regulation of phosphoprotein phosphatase activity | platelet degranulation | negative regulation of cellular process | regulation of phosphatase activity | response to metal ion | microtubule cytoskeleton organization | positive regulation of cyclic-nucleotide phosphodiesterase activity | nervous system development | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | regulation of cell communication by electrical coupling involved in cardiac conduction | polyol metabolic process | positive regulation of phosphate metabolic process | positive regulation of cation channel activity | membrane organization | microtubule-based process | protein phosphatase activator activity | interaction with symbiont | positive regulation of dephosphorylation | cellular process | secretion | channel regulator activity | localization | cellular homeostasis | regulation of calcium-mediated signaling | passive transmembrane transporter activity | negative regulation of signaling | kinase regulator activity | establishment of protein localization to mitochondrion | positive regulation of nitric-oxide synthase activity | positive regulation of protein kinase activity | macromolecule localization | positive regulation of oxidoreductase activity | microtubule organizing center organization | response to corticosterone | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | interspecies interaction between organisms | regulation of immune response | regulation of cellular process | regulation of metabolic process | positive regulation of ryanodine-sensitive calcium-release channel activity | regulation of cytosolic calcium ion concentration | transmembrane transporter activity | positive regulation of cellular protein metabolic process | ligand-gated ion channel activity | cellular component organization | negative regulation of calcium-mediated signaling | MAPK cascade | calcium ion homeostasis | regulation of cell division | head development | muscle contraction | response to stimulus | ion gated channel activity | negative regulation of peptidyl-threonine phosphorylation | ion channel inhibitor activity | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | phosphatase activator activity | positive regulation of cation transmembrane transport | alcohol metabolic process | establishment of protein localization to mitochondrial membrane | regulation of cardiac muscle contraction by calcium ion signaling | regulation of blood circulation | positive regulation of phosphatase activity | regulation of high voltage-gated calcium channel activity | regulation of heart rate | negative regulation of transporter activity | cellular localization | secretion by cell | response to alcohol | midbrain development | negative regulation of transport | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | cofactor metabolic process | protein modification process | modulation of chemical synaptic transmission | mitochondrion organization | macromolecule modification | cell-cell signaling | negative regulation of calcium ion transmembrane transport | negative regulation of transmembrane transport | positive regulation of protein dephosphorylation | activation of protein kinase activity | regulation of intracellular transport | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | regulation of neurotransmitter levels | positive regulation of monooxygenase activity | organic hydroxy compound metabolic process | response to nitrogen compound | regulation of calcium ion transport into cytosol | system development | nitrogen compound metabolic process | regulation of signal transduction | detection of chemical stimulus | Wnt signaling pathway | negative regulation of phosphate metabolic process | positive regulation of calcium ion transmembrane transport | channel inhibitor activity | multicellular organism development | detection of calcium ion | regulation of synaptic vesicle exocytosis | phosphorus metabolic process | adenylate cyclase activator activity | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | ion transmembrane transport | regulation of nitric-oxide synthase activity | protein localization to membrane | response to ketone | response to lipid | cell cycle | regulation of protein autophosphorylation | organophosphate metabolic process | modification of morphology or physiology of other organism | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | positive regulation of ion transmembrane transport | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | small molecule metabolic process | negative regulation of release of sequestered calcium ion into cytosol | positive regulation by host of symbiont cAMP-mediated signal transduction | positive regulation of intracellular signal transduction | response to corticosteroid | vesicle-mediated transport | substantia nigra development | ion transmembrane transporter activity | protein localization to organelle | positive regulation of hydrolase activity | Fc-epsilon receptor signaling pathway | second-messenger-mediated signaling | positive regulation of calcium-mediated signaling | non-canonical Wnt signaling pathway | regulation of release of sequestered calcium ion into cytosol | negative regulation of ion transmembrane transport | negative regulation of calcium ion transmembrane transporter activity | regulation of cellular protein metabolic process | phosphorylation | negative regulation of ion transport | regulated exocytosis | regulation of calcium ion transmembrane transport | regulation of synaptic vesicle endocytosis | regulation of synaptic vesicle transport | response to toxic substance | regulation of voltage-gated calcium channel activity | response to xenobiotic stimulus | regulation of heart contraction | protein phosphorylation | cation homeostasis | phosphate-containing compound metabolic process | regulation of striated muscle contraction | mitochondrial membrane organization | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of cytokinesis | negative regulation of cation channel activity | positive regulation of transporter activity | positive regulation of sequestering of calcium ion | negative regulation of calcium ion transport | regulation of cardiac muscle contraction | regulation of protein metabolic process | positive regulation of signal transduction | regulation of cAMP-mediated signaling | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | positive regulation of transport | negative regulation of calcium ion transport into cytosol | positive regulation of molecular function | calcium-mediated signaling | regulation of ryanodine-sensitive calcium-release channel activity | establishment of protein localization to membrane | calcium channel regulator activity | Wnt signaling pathway, calcium modulating pathway | activation of adenylate cyclase activity | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | regulation of protein dephosphorylation | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | regulation of exocytosis | establishment of protein localization to organelle | anatomical structure development | kinase activator activity | response to amine | cell surface receptor signaling pathway | metabolic process | response to mineralocorticoid | cellular protein localization | regulation of vesicle-mediated transport | nitric-oxide synthase regulator activity | chemical homeostasis | Ras guanyl-nucleotide exchange factor activity | regulation of secretion | negative regulation of ion transmembrane transporter activity | organic substance metabolic process | regulation of sequestering of calcium ion | regulation of cell communication by electrical coupling | animal organ development | positive regulation of ion transport | negative regulation of cellular protein metabolic process | protein phosphatase regulator activity | positive regulation of cAMP-mediated signaling | positive regulation of kinase activity | ion homeostasis | regulation of phosphate metabolic process | cytoskeleton organization | regulation of ion transmembrane transport | establishment of protein localization | regulation of regulated secretory pathway | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | transmembrane transport | signaling | regulation of oxidoreductase activity | response to organic cyclic compound | regulation of endocytosis | positive regulation of calcium ion transmembrane transporter activity | calcium channel inhibitor activity | regulation of transmembrane transporter activity | protein localization | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | cellular macromolecule localization | channel activity | positive regulation of calcium ion transport into cytosol | regulation of synaptic vesicle recycling | regulation of ion transport | regulation of G-protein coupled receptor protein signaling pathway | regulation of phosphoprotein phosphatase activity | regulation of rhodopsin mediated signaling pathway | kinase activity | developmental process | organelle organization | negative regulation of ryanodine-sensitive calcium-release channel activity | Fc receptor signaling pathway | regulation of cardiac conduction | regulation of calcium ion transport | cellular protein modification process | positive regulation of protein autophosphorylation | regulation of transport | regulation of cation channel activity | response to organonitrogen compound | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | cellular metal ion homeostasis | inositol-1,4,5-trisphosphate 3-kinase activity | regulation of calcium ion-dependent exocytosis | response to calcium ion | central nervous system development | ion channel activity | positive regulation of metabolic process | regulation of calcium ion transmembrane transporter activity | response to amphetamine | ion transport | cellular metabolic process | response to steroid hormone | divalent inorganic cation homeostasis | substrate-specific channel activity | regulation of cellular component organization | positive regulation of calcium ion transport | muscle system process | phosphatase regulator activity | positive regulation of signaling | neural nucleus development | inositol phosphate metabolic process | signal transduction | regulation of signaling | response to glucocorticoid | regulation of neurotransmitter secretion | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | exocytic vesicle | integral component of membrane | intracellular membrane-bounded organelle | synapse | catalytic complex | neuron projection | organelle membrane | sarcomere | microtubule organizing center | cytoplasmic vesicle | cell | nuclear lumen | distal axon | intrinsic component of membrane | transport vesicle membrane | myofibril | microtubule | cytoplasm | spindle | intracellular organelle | contractile fiber | presynapse | centrosome | protein-containing complex | cell projection | secretory vesicle | endomembrane system | nucleoplasm | plasma membrane | exocytic vesicle membrane | vesicle | transport vesicle | microtubule cytoskeleton | mitochondrion | site of polarized growth | spindle pole | spindle microtubule | synaptic vesicle | calcium channel complex | extracellular region | membrane-bounded organelle | nucleus | organelle | vesicle membrane | mitochondrial envelope | cell periphery | axon | membrane-enclosed lumen | transmembrane transporter complex | growth cone | cation channel complex | ion channel complex | synaptic vesicle membrane | mitochondrial membrane | cytosol | intracellular vesicle | cytoskeleton | intracellular | myelin sheath | membrane | supramolecular complex | cytoplasmic vesicle membrane
