QuickView for CAPN6 (gene)

Gene Symbol:

CAPN6 Homo sapiens

Full name:

calpain 6

Synonyms:

CANPX, CAPNX, CalpM, DJ914P14.1, calpain-6, calpain-like protease X-linked, calpamodulin

Genomic Location:

Chr X: 110374987-110400407

Description:

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenera...

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Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  AP1_C ,  TGIF_01 ,  TGANTCA_AP1_C ,  NFAT_Q6 ,  ATF4_Q2 ,  WGTTNNNNNAAA_UNKNOWN ,  WTGAAAT_UNKNOWN ,  NFE2_01 ,  CEBPB_01 ,  AP1_Q6_01 ,  CAGGTA_AREB6_01 ,  ATACCTC_MIR202 ,  AGCTCCT_MIR28 ,  TATA_C ,  TGCCTTA_MIR124A ,  BACH2_01 ,  ACTGCCT_MIR34B ,  TAXCREB_02 ,  NRF2_Q4 ,  RNGTGGGC_UNKNOWN ,  GTGCCTT_MIR506 ,  AATGTGA_MIR23A_MIR23B ,  BACH1_01 ,  STAT5A_04 ,  WTTGKCTG_UNKNOWN ,  CP2_02 ,  GTGGGTGK_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  CCATCCA_MIR432 ,  AACTTT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  USF_02 ,  CCACACA_MIR147 ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-28 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

Cytogenetic Map:

Xq23

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