QuickView for CARD11 (gene)

Gene Symbol:

CARD11 Homo sapiens

Full name:

caspase recruitment domain family member 11

Synonyms:

BENTA, BIMP3, CARMA1, IMD11, IMD11A, PPBL, caspase recruitment domain-containing protein 11, CARD-containing MAGUK protein 1, bcl10-interacting maguk protein 3, carma 1

Genomic Location:

Chr 7: 2912295-3050105

Description:

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characterist...

View Full Description

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TGATTTRY_GFI1_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-155

Cytogenetic Map:

7p22.2

search → result