QuickView for CASP-2 (gene)
- Gene Symbol:
- CASP2
Homo sapiens - Full name:
- caspase 2
- Synonyms:
- CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57, caspase-2, caspase 2 apoptosis-related cysteine peptidase, neural precursor cell expressed developmentally down-regulated protein 2, protease ICH-1, protein phosphatase 1, regulatory subunit 57
- Genomic Location:
- Chr 7: 142695524-142714907
- Description:
-
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this ge...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
7q34
GO Molecular Function
cysteine-type endopeptidase activity involved in apoptotic process | enzyme binding | hydrolase activity | cysteine-type peptidase activity | catalytic activity | protein domain specific binding | identical protein binding | cysteine-type endopeptidase activity | protein binding | endopeptidase activity | peptidase activity
GO Biological Process
brain development | regulation of cell cycle process | developmental process involved in reproduction | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | regulation of cell cycle G1/S phase transition | gonad development | regulation of programmed cell death | female gonad development | eye development | negative regulation of cellular process | protein processing | cell differentiation | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | regulation of neuron death | neural retina development | cellular process | extrinsic apoptotic signaling pathway | mitotic DNA integrity checkpoint | negative regulation of G1/S transition of mitotic cell cycle | reproductive system development | cysteine-type endopeptidase activity involved in apoptotic process | multicellular organismal reproductive process | negative regulation of apoptotic process | regulation of cell cycle | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | signal transduction involved in mitotic DNA damage checkpoint | luteolysis | development of primary sexual characteristics | head development | response to stimulus | cellular response to mechanical stimulus | regulation of mitotic cell cycle phase transition | response to stress | ovulation cycle | regulation of cell cycle phase transition | execution phase of apoptosis | programmed cell death | development of primary female sexual characteristics | reproduction | rhythmic process | cysteine-type peptidase activity | apoptotic process | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | mitotic DNA damage checkpoint | multicellular organism development | cellular response to DNA damage stimulus | positive regulation of cell cycle | signal transduction in response to DNA damage | cellular response to stress | cell cycle | regulation of cell cycle arrest | positive regulation of neuron death | protein maturation | regulation of apoptotic signaling pathway | signal transduction involved in cell cycle checkpoint | programmed cell death involved in cell development | sensory organ development | ovulation cycle process | mitotic G1 DNA damage checkpoint | cell communication | regulation of neuron apoptotic process | positive regulation of signal transduction | cysteine-type endopeptidase activity | apoptotic signaling pathway | regulation of mitotic cell cycle | positive regulation of cell cycle arrest | multicellular organism reproduction | protein metabolic process | G1 DNA damage checkpoint | retina development in camera-type eye | response to mechanical stimulus | positive regulation of neuron apoptotic process | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | positive regulation of cell death | organic substance metabolic process | cell death | animal organ development | gene expression | positive regulation of programmed cell death | signal transduction involved in mitotic cell cycle checkpoint | camera-type eye development | negative regulation of cell cycle | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | signaling | endopeptidase activity | cell development | extrinsic apoptotic signaling pathway in absence of ligand | signal transduction involved in DNA damage checkpoint | reproductive structure development | developmental process | positive regulation of cell cycle process | mitotic G1/S transition checkpoint | signal transduction involved in mitotic G1 DNA damage checkpoint | central nervous system development | mitotic cell cycle checkpoint | negative regulation of cell cycle process | peptidase activity | female sex differentiation | regulation of cell death | sex differentiation | ectopic germ cell programmed cell death | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | aging | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular | membrane
