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QuickView for CASP10 (gene)


Gene Symbol:
CASP10 Homo sapiens Homo sapiens
Full name:
caspase 10
Synonyms:
ALPS2, FLICE2, MCH4, caspase-10, CASP-10, FADD-like ICE2, FAS-associated death domain protein interleukin-1B-converting enzyme 2, ICE-like apoptotic protease 4, apoptotic protease MCH-4, caspase 10 apoptosis-related cysteine peptidase, caspase 10, apoptosis-related cysteine protease, interleukin-1B-converting enzyme 2
Genomic Location:
Chr 2: 201755866-201802355
Description:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, th...
Orthologs:
Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 2
2q33.1





GO Molecular Function

cysteine-type endopeptidase activity involved in apoptotic signaling pathway | cysteine-type endopeptidase activity involved in apoptotic process | enzyme binding | hydrolase activity | cysteine-type peptidase activity | catalytic activity | protein domain specific binding | ubiquitin-like protein ligase binding | death effector domain binding | cysteine-type endopeptidase activity | protein binding | ubiquitin protein ligase binding | endopeptidase activity | peptidase activity

GO Biological Process

regulation of cysteine-type endopeptidase activity | positive regulation of apoptotic process | proteolysis | regulation of programmed cell death | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | cellular process | cysteine-type endopeptidase activity involved in apoptotic process | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | response to stimulus | positive regulation of protein metabolic process | positive regulation of peptidase activity | positive regulation of cysteine-type endopeptidase activity | execution phase of apoptosis | programmed cell death | positive regulation of proteolysis | cysteine-type peptidase activity | apoptotic process | nitrogen compound metabolic process | regulation of signal transduction | regulation of peptidase activity | regulation of catalytic activity | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of intracellular signal transduction | positive regulation of hydrolase activity | regulation of cellular protein metabolic process | positive regulation of endopeptidase activity | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | cysteine-type endopeptidase activity | apoptotic signaling pathway | positive regulation of molecular function | protein metabolic process | regulation of intracellular signal transduction | cell surface receptor signaling pathway | metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell death | organic substance metabolic process | cell death | positive regulation of programmed cell death | regulation of cell communication | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | endopeptidase activity | regulation of endopeptidase activity | positive regulation of metabolic process | peptidase activity | regulation of cell death | regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process

GO Cellular Component

ripoptosome | catalytic complex | cell | plasma membrane protein complex | cytoplasm | death-inducing signaling complex | protein-containing complex | CD95 death-inducing signaling complex | plasma membrane | cell periphery | cytosol | intracellular | membrane