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QuickView for CAST (gene)


Gene Symbol:
CAST Homo sapiens Homo sapiens
Full name:
calpastatin
Synonyms:
BS-17, PLACK, calpastatin, calpain inhibitor, sperm BS-17 component
Genomic Location:
Chr 5: 96023697-96136143
Description:
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion even...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for miR-103 Predicted Gene Targets for miR-128 Predicted Gene Targets for miR-135 Predicted Gene Targets for miR-15 Predicted Gene Targets for miR-141 Predicted Gene Targets for miR-218 Predicted Gene Targets for miR-24 Predicted Gene Targets for miR-25 Predicted Gene Targets for miR-26 Predicted Gene Targets for miR-299
Cytogenetic Map:
chr 5
5q15





GO Molecular Function

endopeptidase inhibitor activity | cadherin binding | enzyme binding | nucleic acid binding | enzyme inhibitor activity | molecular function regulator | calcium-dependent cysteine-type endopeptidase inhibitor activity | organic cyclic compound binding | cell adhesion molecule binding | protein binding | peptidase inhibitor activity | enzyme regulator activity | protease binding | heterocyclic compound binding | cysteine-type endopeptidase inhibitor activity | RNA binding

GO Biological Process

regulation of cysteine-type endopeptidase activity | endopeptidase inhibitor activity | regulation of programmed cell death | negative regulation of cysteine-type endopeptidase activity | negative regulation of cellular process | negative regulation of proteolysis | cellular process | negative regulation of apoptotic process | regulation of proteolysis | negative regulation of cellular metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | cellular component organization | enzyme inhibitor activity | negative regulation of epithelial cell apoptotic process | negative regulation of metabolic process | regulation of protein processing | molecular function regulator | negative regulation of catalytic activity | regulation of peptidase activity | regulation of catalytic activity | negative regulation of peptidase activity | regulation of gene expression | inhibition of cysteine-type endopeptidase activity | regulation of nitrogen compound metabolic process | synapse organization | regulation of cellular protein metabolic process | calcium-dependent cysteine-type endopeptidase inhibitor activity | regulation of epithelial cell apoptotic process | regulation of cellular metabolic process | negative regulation of protein processing | regulation of protein metabolic process | negative regulation of type B pancreatic cell apoptotic process | negative regulation of programmed cell death | presynaptic active zone organization | negative regulation of gene expression | negative regulation of cellular protein metabolic process | negative regulation of protein metabolic process | negative regulation of molecular function | peptidase inhibitor activity | enzyme regulator activity | regulation of endopeptidase activity | negative regulation of hydrolase activity | regulation of cell death | cysteine-type endopeptidase inhibitor activity | negative regulation of cell death | negative regulation of endopeptidase activity

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | endomembrane system | membrane-bounded organelle | organelle | cytosol | intracellular | membrane