QuickView for CB1R (gene)

Gene Symbol:

CNR1 Homo sapiens

Full name:

cannabinoid receptor 1

Synonyms:

CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, cannabinoid receptor 1, cannabinoid receptor 1 (brain), central cannabinoid receptor

Genomic Location:

Chr 6: 88906302-88911775

Description:

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-depen...

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This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TCTGGAC_MIR198 ,  CACTGTG_MIR128A_MIR128B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CAGTGTT_MIR141_MIR200A ,  CTTTGTA_MIR524 ,  TATAAA_TATA_01 ,  TGTATGA_MIR4853P ,  P53_02 ,  RRAGTTGT_UNKNOWN ,  GTTTGTT_MIR495 ,  GTATGAT_MIR154_MIR487 ,  TTGTTT_FOXO4_01 ,  GATA4_Q3 ,  CCCNNNNNNAAGWT_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  FOXO4_02 ,  CACTTTG_MIR520G_MIR520H

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

6q15

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