QuickView for CBFA2T1 (gene)

Gene Symbol:

RUNX1T1 Homo sapiens

Full name:

RUNX1 translocation partner 1

Synonyms:

AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2, protein CBFA2T1, acute myelogenous leukemia 1 translocation 1, cyclin-D related, core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related, eight twenty one protein, myeloid translocation gene on 8q22, runt related transcription factor 1; translocated to, 1 (cyclin D related), zinc finger MYND domain-containing protein 2

Genomic Location:

Chr 8: 93040328-93176619

Description:

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric...

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This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  MYOD_Q6_01 ,  IRF1_01 ,  OCT1_07 ,  SMTTTTGT_UNKNOWN ,  TGANTCA_AP1_C ,  CCCACAT_MIR2993P ,  AGTTCTC_MIR146A_MIR146B ,  TAL1ALPHAE47_01 ,  TTANTCA_UNKNOWN ,  TCANNTGAY_SREBP1_01 ,  AREB6_02 ,  FOX_Q2 ,  EFC_Q6 ,  MIF1_01 ,  GATA_Q6 ,  GATA_C ,  CACGTG_MYC_Q2 ,  GCANCTGNY_MYOD_Q6 ,  FOXD3_01 ,  HFH1_01 ,  VDR_Q6 ,  ARP1_01 ,  WGTTNNNNNAAA_UNKNOWN ,  GATAAGR_GATA_C ,  CTTTGA_LEF1_Q2 ,  TTTNNANAGCYR_UNKNOWN ,  GR_Q6_01 ,  MYB_Q5_01 ,  GATA1_04 ,  TGACCTY_ERR1_Q2 ,  HEB_Q6 ,  WTGAAAT_UNKNOWN ,  TATAAA_TATA_01 ,  EVI1_03 ,  CDPCR3HD_01 ,  TGTATGA_MIR4853P ,  TAL1BETAE47_01 ,  CDP_02 ,  CCTGTGA_MIR513 ,  GGATTA_PITX2_Q2 ,  FREAC3_01 ,  CAGGTG_E12_Q6 ,  TTCYRGAA_UNKNOWN ,  EVI1_02 ,  EVI1_05 ,  GTTTGTT_MIR495 ,  ATGCTGC_MIR103_MIR107 ,  GCAAAAA_MIR129 ,  HNF3B_01 ,  CDPCR1_01 ,  AREB6_01 ,  TGCTGAY_UNKNOWN ,  USF_C ,  LMO2COM_02 ,  YKACATTT_UNKNOWN ,  GATA6_01 ,  OCT1_03 ,  CCCNNGGGAR_OLF1_01 ,  S8_01 ,  NKX61_01 ,  IRF_Q6 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  RAAGNYNNCTTY_UNKNOWN ,  TAATAAT_MIR126 ,  CTTTAAR_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  HFH4_01 ,  GCCNNNWTAAR_UNKNOWN ,  MEIS1_01 ,  GATA1_02 ,  YCATTAA_UNKNOWN ,  MYB_Q6 ,  AATGTGA_MIR23A_MIR23B ,  EN1_01 ,  OCT1_02 ,  HAND1E47_01 ,  TAATTA_CHX10_01 ,  YGCGYRCGC_UNKNOWN ,  TTGTTT_FOXO4_01 ,  AP2REP_01 ,  CHOP_01 ,  CART1_01 ,  GATA4_Q3 ,  IK2_01 ,  MSX1_01 ,  ARGGGTTAA_UNKNOWN ,  GATA1_05 ,  WTTGKCTG_UNKNOWN ,  IRF7_01 ,  YTAATTAA_LHX3_01 ,  TAL1BETAITF2_01 ,  KMCATNNWGGA_UNKNOWN ,  GGCCAGT_MIR193A_MIR193B ,  ACAWNRNSRCGG_UNKNOWN ,  TGATTTRY_GFI1_01 ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  TCCATTKW_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  ER_Q6_01 ,  CAGCTG_AP4_Q5 ,  MMEF2_Q6 ,  FOXM1_01 ,  AACTTT_UNKNOWN ,  TTANWNANTGGM_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  TGACATY_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ERR1_Q2 ,  GGCKCATGS_UNKNOWN ,  PAX2_02 ,  HIF1_Q3 ,  CEBPGAMMA_Q6 ,  FREAC4_01 ,  FOXO4_02 ,  MYB_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-192 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-299-3p ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-505

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Cytogenetic Map:

8q21.3

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