QuickView for CBFA2T3;jsessionid=206034EAB53DC5CA51CD8722C99A1856 (gene)

Gene Symbol:

CBFA2T3 Homo sapiens

Full name:

CBFA2/RUNX1 translocation partner 3

Synonyms:

ETO2, MTG16, MTGR2, RUNX1T3, ZMYND4, protein CBFA2T3, MTG8-related gene 2, MTG8-related protein 2, core-binding factor, runt domain, alpha subunit 2; translocated to, 3, myeloid translocation gene 8 and 16b, myeloid translocation gene on chromosome 16 protein, zinc finger MYND domain-containing protein 4

Genomic Location:

Chr 16: 87468768-87570902

Description:

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric ...

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This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  TAL1ALPHAE47_01 ,  ETS_Q4 ,  TCANNTGAY_SREBP1_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  SMAD3_Q6 ,  GCANCTGNY_MYOD_Q6 ,  E2A_Q2 ,  OCT_C ,  HEB_Q6 ,  ACTGTGA_MIR27A_MIR27B ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  GGGAGGRR_MAZ_Q6 ,  RGAANNTTC_HSF1_01 ,  TAL1BETAE47_01 ,  TAATGTG_MIR323 ,  RP58_01 ,  CAGGTG_E12_Q6 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  AP4_Q6 ,  RRAGTTGT_UNKNOWN ,  ACTACCT_MIR196A_MIR196B ,  GGGCGGR_SP1_Q6 ,  GACAATC_MIR219 ,  E47_01 ,  HSF2_01 ,  RNGTGGGC_UNKNOWN ,  AATGTGA_MIR23A_MIR23B ,  TTGCCAA_MIR182 ,  AP4_Q6_01 ,  HEN1_02 ,  RGAGGAARY_PU1_Q6 ,  SMAD4_Q6 ,  CTGCAGY_UNKNOWN ,  TAL1BETAITF2_01 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ETS1_B ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182

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Cytogenetic Map:

16q24.3

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