QuickView for CBX3;jsessionid=1CC06D7A04845C52183B5DE9FB1D9685 (gene)

Gene Symbol:

CBX3 Homo sapiens

Full name:

chromobox 3

Synonyms:

HECH, HP1-GAMMA, HP1Hs-gamma, chromobox protein homolog 3, HP1 gamma homolog, chromobox homolog 3 (HP1 gamma homolog, Drosophila), heterochromatin protein 1 homolog gamma, heterochromatin protein HP1 gamma, heterochromatin-like protein 1, modifier 2 protein

Genomic Location:

Chr 7: 26207624-26219501

Description:

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein...

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At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

STAT1_02 ,  E2F4DP1_01 ,  TTCNRGNNNNTTC_HSF_Q6 ,  ATF4_Q2 ,  TTTGTAG_MIR520D ,  WGTTNNNNNAAA_UNKNOWN ,  ACTTTAT_MIR1425P ,  IRF1_Q6 ,  STAT1_03 ,  CREB_Q4 ,  E2F1_Q4 ,  CTTTGTA_MIR524 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  CREBP1_Q2 ,  CDPCR3HD_01 ,  RGAANNTTC_HSF1_01 ,  HSF1_01 ,  TTCYRGAA_UNKNOWN ,  TGCGCANK_UNKNOWN ,  E2F1DP2_01 ,  GCGNNANTTCC_UNKNOWN ,  E4F1_Q6 ,  HSF_Q6 ,  KCCGNSWTTT_UNKNOWN ,  E2F1DP1_01 ,  E2F_02 ,  CREB_Q2 ,  E2F4DP2_01 ,  CTTTGT_LEF1_Q2 ,  MZF1_02 ,  PAX4_03 ,  HNF6_Q6 ,  GGGTGGRR_PAX4_03 ,  E2F1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

7p15.2

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