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QuickView for CCL2;jsessionid=8838F6B264F425CDD2C620D306F7AB40 (gene)


Gene Symbol:
CCL2 Homo sapiens Homo sapiens
Full name:
C-C motif chemokine ligand 2
Synonyms:
GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine 2, chemokine (C-C motif) ligand 2, monocyte chemoattractant protein-1, monocyte chemotactic and activating factor, monocyte chemotactic protein 1, monocyte secretory protein JE, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je), small inducible cytokine subfamily A (Cys-Cys), member 2, small-inducible cytokine A2
Genomic Location:
Chr 17: 29606409-29608335
Description:
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q12


Transcripts Names
NM_002982
Protein Names
Q9UDF3
B2R4V3
P13500



GO Molecular Function

chemokine activity | CCR chemokine receptor binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | catalytic activity | CCR2 chemokine receptor binding | chemokine receptor binding | protein binding | receptor regulator activity | transferase activity, transferring phosphorus-containing groups | G-protein coupled receptor binding | phosphotransferase activity, alcohol group as acceptor | receptor ligand activity | protein kinase activity | cytokine activity | transferase activity | kinase activity

GO Biological Process

regulation of leukocyte chemotaxis | regulation of ERK1 and ERK2 cascade | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | macrophage chemotaxis | macrophage migration | response to endoplasmic reticulum stress | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | negative regulation of lymphocyte chemotaxis | cell motility | regulation of cell morphogenesis | response to lipopolysaccharide | intracellular signal transduction | positive regulation of apoptotic process | regulation of localization | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | regulation of immune system process | regulation of cell shape | negative regulation of vascular endothelial cell proliferation | negative regulation of neuron death | negative regulation of cellular process | cellular response to tumor necrosis factor | positive regulation of lymphocyte activation | cell differentiation | JAK-STAT cascade | chemokine-mediated signaling pathway | defense response | nervous system development | regulation of G1/S transition of mitotic cell cycle | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | PERK-mediated unfolded protein response | blood vessel morphogenesis | regulation of neuron death | positive regulation of GTPase activity | cellular process | eosinophil chemotaxis | regulation of cell motility | localization | cellular homeostasis | T cell extravasation | chemokine activity | negative regulation of G1/S transition of mitotic cell cycle | endoplasmic reticulum unfolded protein response | regulation of chemotaxis | negative regulation of apoptotic process | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | granulocyte chemotaxis | positive regulation of epithelial cell apoptotic process | interspecies interaction between organisms | positive regulation of apoptotic cell clearance | negative regulation of cell motility | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | negative regulation of chemotaxis | cellular response to molecule of bacterial origin | positive regulation of cellular protein metabolic process | cellular response to unfolded protein | response to topologically incorrect protein | cellular component organization | MAPK cascade | viral life cycle | cellular response to topologically incorrect protein | cellular response to interferon-gamma | helper T cell extravasation | response to stimulus | vasculature development | regulation of mitotic cell cycle phase transition | cellular response to fibroblast growth factor stimulus | neutrophil chemotaxis | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | negative regulation of natural killer cell chemotaxis | regulation of cell proliferation | lymphocyte chemotaxis | tube morphogenesis | positive regulation of cell-cell adhesion | regulation of cell cycle phase transition | positive regulation of cell activation | positive regulation of endothelial cell apoptotic process | negative regulation of leukocyte chemotaxis | cardiovascular system development | response to molecule of bacterial origin | positive regulation of T cell activation | cellular response to organic cyclic compound | regulation of phagocytosis | G-protein coupled receptor signaling pathway | monocyte chemotaxis | protein modification process | regulation of cell adhesion | macromolecule modification | cell chemotaxis | molecular function regulator | blood vessel development | leukocyte migration | astrocyte cell migration | locomotion | negative regulation of neuron apoptotic process | protein kinase B signaling | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | multicellular organism development | cell migration | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | ER-nucleus signaling pathway | regulation of phosphorylation | positive regulation of calcium ion import | regulation of T cell activation | negative regulation of lymphocyte migration | cellular response to stress | response to lipid | viral genome replication | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | regulation of cell migration | glial cell migration | lymphocyte migration | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of cellular component movement | regulation of endothelial cell apoptotic process | positive regulation of hydrolase activity | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | angiogenesis | phosphorylation | regulation of GTPase activity | regulation of epithelial cell apoptotic process | protein phosphorylation | regulation of leukocyte migration | phosphate-containing compound metabolic process | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | humoral immune response | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | homeostatic process | regulation of protein phosphorylation | regulation of locomotion | lipopolysaccharide-mediated signaling pathway | positive regulation of transport | viral process | regulation of mitotic cell cycle | regulation of apoptotic cell clearance | positive regulation of molecular function | regulation of signaling receptor activity | receptor regulator activity | negative regulation of epithelial cell proliferation | protein metabolic process | positive regulation of protein modification process | response to organic substance | eosinophil migration | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | regulation of vesicle-mediated transport | negative regulation of endothelial cell proliferation | positive regulation of cell death | cell adhesion | receptor ligand activity | immune response | protein kinase activity | cytokine activity | organic substance metabolic process | animal organ development | positive regulation of ion transport | regulation of endothelial cell proliferation | regulation of cell activation | negative regulation of cellular component movement | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of phagocytosis | regulation of phosphate metabolic process | cytoskeleton organization | response to interferon-gamma | negative regulation of glial cell apoptotic process | positive regulation of MAPK cascade | regulation of lymphocyte chemotaxis | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | regulation of calcium ion import | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | signaling | response to organic cyclic compound | regulation of endocytosis | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | response to unfolded protein | anatomical structure morphogenesis | response to biotic stimulus | negative regulation of leukocyte migration | regulation of developmental process | regulation of ion transport | kinase activity | developmental process | organelle organization | cellular response to interleukin-1 | regulation of calcium ion transport | cellular protein modification process | cellular extravasation | tube development | regulation of transport | negative regulation of cell proliferation | regulation of cell-cell adhesion | innate immune response | response to fibroblast growth factor | T cell migration | positive regulation of metabolic process | immune system process | cellular metabolic process | negative regulation of cell cycle process | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | negative regulation of cell death | neutrophil migration | circulatory system development | chemotaxis | negative regulation of locomotion | positive regulation of endocytosis | positive regulation of leukocyte cell-cell adhesion | regulation of lymphocyte migration | regulation of cellular component organization | positive regulation of calcium ion transport | response to other organism | positive regulation of signaling | signal transduction | mononuclear cell migration | regulation of signaling | positive regulation of nitric-oxide synthase biosynthetic process | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

cell | extracellular region | extracellular space | intracellular