Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for CCL3 (gene)


Gene Symbol:
CCL3 Homo sapiens Homo sapiens
Full name:
C-C motif chemokine ligand 3
Synonyms:
G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine 3, G0/G1 switch regulatory protein 19-1, PAT 464.1, SIS-beta, chemokine (C-C motif) ligand 3, macrophage inflammatory protein 1-alpha, small inducible cytokine A3 (homologous to mouse Mip-1a), tonsillar lymphocyte LD78 alpha protein
Genomic Location:
Chr 17: 31439715-31441619
Description:
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 17
17q12


Transcripts Names
NM_002983
Protein Names
A0N0R1
P10147



GO Molecular Function

enzyme activator activity | lipase activator activity | calcium-dependent protein kinase activity | chemokine activity | CCR chemokine receptor binding | signaling receptor binding | cytokine receptor binding | protein serine/threonine kinase activity | protein kinase C activity | molecular function regulator | catalytic activity | calcium-dependent protein serine/threonine kinase activity | identical protein binding | calcium-dependent protein kinase C activity | chemokine receptor binding | protein binding | receptor regulator activity | CCR1 chemokine receptor binding | transferase activity, transferring phosphorus-containing groups | G-protein coupled receptor binding | phosphotransferase activity, alcohol group as acceptor | receptor ligand activity | protein kinase activity | cytokine activity | chemoattractant activity | transferase activity | phospholipase activator activity | enzyme regulator activity | CCR5 chemokine receptor binding | kinase activity

GO Biological Process

regulation of leukocyte chemotaxis | regulation of ERK1 and ERK2 cascade | regulation of interleukin-1 beta production | positive regulation of locomotion | negative regulation of immune system process | macrophage chemotaxis | macrophage migration | exocytosis | response to cytokine | response to interleukin-1 | cell motility | regulation of cell morphogenesis | response to lipopolysaccharide | intracellular signal transduction | enzyme activator activity | calcium ion transmembrane import into cytosol | positive regulation of apoptotic process | cytosolic calcium ion transport | regulation of localization | regulation of programmed cell death | establishment of localization | regulation of immune system process | regulation of cell shape | negative regulation of cellular process | cellular response to tumor necrosis factor | cell differentiation | chemokine-mediated signaling pathway | defense response | nervous system development | cellular chemical homeostasis | neurogenesis | negative regulation of osteoclast differentiation | lipase activator activity | positive regulation of interleukin-1 beta secretion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | calcium-dependent protein kinase activity | positive regulation of protein secretion | interaction with symbiont | regulation of neuron death | positive regulation of GTPase activity | cellular process | secretion | eosinophil chemotaxis | leukocyte degranulation | regulation of cell motility | localization | cellular homeostasis | regulation of calcium-mediated signaling | metal ion transport | chemokine activity | regulation of chemotaxis | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | granulocyte chemotaxis | establishment of localization in cell | regulation of bone mineralization | regulation of behavior | regulation of myeloid leukocyte differentiation | regulation of neurological system process | regulation of cell differentiation | interspecies interaction between organisms | T cell chemotaxis | regulation of protein kinase B signaling | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | regulation of cytosolic calcium ion concentration | cellular response to molecule of bacterial origin | positive regulation of cellular protein metabolic process | cellular component organization | MAPK cascade | calcium ion homeostasis | cellular response to interferon-gamma | positive regulation of tumor necrosis factor production | negative regulation of biomineral tissue development | calcium ion transport into cytosol | regulation of peptide secretion | response to stimulus | positive regulation of interleukin-1 beta production | positive regulation of natural killer cell chemotaxis | neutrophil chemotaxis | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | response to stress | leukocyte activation involved in immune response | lymphocyte chemotaxis | protein serine/threonine kinase activity | protein kinase C activity | cellular localization | divalent metal ion transport | secretion by cell | response to alcohol | positive regulation of cytokine secretion | response to molecule of bacterial origin | cellular response to organic cyclic compound | regulation of protein transport | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | monocyte chemotaxis | negative regulation of hemopoiesis | protein modification process | regulation of peptide transport | macromolecule modification | cell-cell signaling | cell chemotaxis | molecular function regulator | positive chemotaxis | metal ion homeostasis | leukocyte migration | astrocyte cell migration | positive regulation of peptide secretion | locomotion | protein kinase B signaling | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | cell migration | calcium ion transmembrane transport | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of inflammatory response | leukocyte mediated immunity | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of phosphorylation | ion transmembrane transport | regulation of sensory perception of pain | regulation of ossification | positive regulation of lymphocyte migration | positive regulation of calcium ion import | regulation of gene expression | positive regulation of chemotaxis | positive regulation of secretion | response to lipid | modification of morphology or physiology of other organism | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | negative regulation of myeloid cell differentiation | calcium-dependent protein serine/threonine kinase activity | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | glial cell migration | lymphocyte migration | response to cholesterol | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of cellular component movement | positive regulation of hydrolase activity | second-messenger-mediated signaling | positive regulation of calcium-mediated signaling | negative regulation of viral process | positive regulation of cell migration | cellular response to cytokine stimulus | calcium-dependent protein kinase C activity | negative regulation of sequestering of calcium ion | regulation of cellular protein metabolic process | phosphorylation | regulated exocytosis | positive regulation of interleukin-1 secretion | positive regulation of neuron death | response to toxic substance | regulation of GTPase activity | protein phosphorylation | regulation of tumor necrosis factor production | cation homeostasis | regulation of leukocyte migration | phosphate-containing compound metabolic process | response to bacterium | regulation of interleukin-1 production | negative regulation by host of viral transcription | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | positive regulation of interleukin-1 production | positive regulation of leukocyte chemotaxis | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | cellular calcium ion homeostasis | homeostatic process | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | positive regulation of transport | regulation of viral process | positive regulation of molecular function | release of sequestered calcium ion into cytosol | calcium-mediated signaling | regulation of cytokine secretion | cation transmembrane transport | regulation of signaling receptor activity | receptor regulator activity | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | eosinophil migration | regulation of hemopoiesis | negative regulation of bone mineralization | negative regulation of ossification | regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of interleukin-1 beta secretion | regulation of RNA biosynthetic process | chemical homeostasis | calcium ion transport | regulation of secretion | positive regulation of cell death | receptor ligand activity | immune response | protein kinase activity | cytokine activity | organic substance metabolic process | regulation of sequestering of calcium ion | chemoattractant activity | negative regulation of gene expression | positive regulation of ion transport | regulation of protein secretion | positive regulation of leukocyte migration | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | ion homeostasis | regulation of phosphate metabolic process | cytoskeleton organization | inorganic cation transmembrane transport | response to interferon-gamma | positive regulation of cytokine production | cell activation | positive regulation of MAPK cascade | regulation of lymphocyte chemotaxis | phospholipase activator activity | positive regulation of protein transport | modulation by host of viral transcription | regulation of osteoclast differentiation | regulation of calcium ion import | regulation of cell communication | transmembrane transport | signaling | response to organic cyclic compound | sarcoplasmic reticulum calcium ion transport | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | release of sequestered calcium ion into cytosol by endoplasmic reticulum | cation transport | response to biotic stimulus | regulation of developmental process | regulation of ion transport | kinase activity | developmental process | organelle organization | eosinophil degranulation | cellular response to interleukin-1 | regulation of calcium ion transport | cellular protein modification process | regulation of transport | innate immune response | cellular metal ion homeostasis | T cell migration | regulation of viral transcription | positive regulation of metabolic process | ossification | osteoblast differentiation | ion transport | immune system process | cellular metabolic process | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | neutrophil migration | regulation of inflammatory response | chemotaxis | divalent inorganic cation homeostasis | negative regulation of viral transcription | negative regulation of myeloid leukocyte differentiation | regulation of lymphocyte migration | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of calcium ion transport | response to other organism | positive regulation of signaling | signal transduction | mononuclear cell migration | regulation of signaling | positive regulation of gene expression | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

cell | cytoplasm | extracellular region | extracellular space | cytosol | intracellular