Correlation Engine 2.0
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QuickView for CCM2 (gene)

Gene Symbol:
CCM2 Homo sapiens Homo sapiens
Full name:
CCM2 scaffolding protein
C7orf22, OSM, PP10187, cerebral cavernous malformations 2 protein, cerebral cavernous malformation 2, malcavernin, osmosensing scaffold for MEKK3
Genomic Location:
Chr 7: 45006312-45082594
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal str...
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 7

GO Molecular Function

protein binding

GO Biological Process

intracellular signal transduction | endothelial cell development | morphogenesis of an epithelium | integrin-mediated signaling pathway | cell differentiation | endothelial cell differentiation | multicellular organism growth | blood vessel morphogenesis | cellular process | epithelial tube morphogenesis | developmental growth | tissue development | regulation of cellular process | epithelium development | cellular component organization | MAPK cascade | blood vessel endothelial cell differentiation | response to stimulus | vasculature development | signal transduction by protein phosphorylation | response to stress | tube morphogenesis | epithelial cell development | cardiovascular system development | protein modification process | pericardium development | embryo development | macromolecule modification | blood vessel development | stress-activated protein kinase signaling cascade | system development | nitrogen compound metabolic process | endothelium development | multicellular organism development | phosphorus metabolic process | cellular response to stress | stress-activated MAPK cascade | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | sensory organ development | chordate embryonic development | cell communication | vasculogenesis | inner ear development | heart development | embryo development ending in birth or egg hatching | venous blood vessel development | protein metabolic process | tissue morphogenesis | anatomical structure development | cell surface receptor signaling pathway | endothelial tube morphogenesis | metabolic process | ear development | organic substance metabolic process | animal organ development | signaling | cell development | cellular protein metabolic process | anatomical structure morphogenesis | developmental process | cellular protein modification process | tube development | epithelial cell differentiation | venous blood vessel morphogenesis | in utero embryonic development | cellular metabolic process | circulatory system development | signal transduction | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | protein-containing complex | mitochondrion | membrane-bounded organelle | organelle | intracellular