QuickView for CCM3 (gene)

Gene Symbol:

PDCD10 Homo sapiens

Full name:

programmed cell death 10

Synonyms:

CCM3, TFAR15, programmed cell death protein 10, TF-1 cell apoptosis-related protein 15, apoptosis-related protein 15, cerebral cavernous malformations 3 protein

Genomic Location:

Chr 3: 168884388-168935345

Description:

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway es...

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This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RYTTCCTG_ETS2_B ,  STAT6_02 ,  CIZ_01 ,  LYF1_01 ,  SREBP1_Q6 ,  IRF1_Q6 ,  GGGAGGRR_MAZ_Q6 ,  CDPCR3HD_01 ,  TAATGTG_MIR323 ,  ACATTCC_MIR1_MIR206 ,  CAGGTG_E12_Q6 ,  ZID_01 ,  ATTCTTT_MIR186 ,  GTTTGTT_MIR495 ,  ATGCTGC_MIR103_MIR107 ,  CDPCR1_01 ,  GGGCGGR_SP1_Q6 ,  ACTAYRNNNCCCR_UNKNOWN ,  PAX6_01 ,  AACATTC_MIR4093P ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  IK3_01 ,  SREBP_Q3 ,  TAL1BETAITF2_01 ,  CTTTGT_LEF1_Q2 ,  P300_01 ,  AACTTT_UNKNOWN ,  GGGTGGRR_PAX4_03 ,  ATGTAGC_MIR221_MIR222

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-505

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Cytogenetic Map:

3q26.1

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